| Tag | Content |
|---|
| CPLM ID | CPLM-013070 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TRAF-type zinc finger domain-containing protein 1 |
Protein Synonyms/Alias | Protein FLN29 |
Gene Name | Trafd1 |
Gene Synonyms/Alias | Fln29 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 103 | ELSVVKLKEHEDYCG | ubiquitination | [1] | | 443 | DVKPESVKGPTYSMS | ubiquitination | [1] | | 484 | RSPPGVLKLNNSDSQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. |
Sequence Annotation | ZN_FING 27 103 TRAF-type.
MOD_RES 326 326 Phosphoserine (By similarity).
MOD_RES 327 327 Phosphoserine (By similarity).
MOD_RES 415 415 Phosphoserine (By similarity).
MOD_RES 469 469 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 580 AA |
Protein Sequence | MAEFRDDQAS RLCDNCKKEI PVFNFTIHEI HCQRNIGVCP VCKEPFPKSD MDIHMAAEHC 60
QVTCKCNKKL EKRQLKQHAE TECPLRLAVC QHCDLELSVV KLKEHEDYCG ARTELCGSCG 120
RNVLVKELKT HPEVCGRVEE EKRTEAAIPP EAYDEPWSQD RIWIASQLLR QIEALDPPMR 180
LPGRPLQAFE ADPFYSRTTS QRSMAAQFPV QNNLFEEQER QERNRSRQSP KDSAENNAHL 240
DFMLALSLQN EGQATSMVEQ GFWESVPEAD PARAGPTSLG DIKGAADEIL LPCEFCEELY 300
PEELLIDHQT SCNPSHALRS LNTGSSSIRG VEDPGTIFQN FLQQATSNQF DTLMGLSSSA 360
AVEDSIIIPC EFCGVQLEEE VLFYHQDQCD QRPATANHRA VEGIPAQDSQ PENTSAELSR 420
RRVKHQGDLS SGYMDDVKPE SVKGPTYSMS PNRTMNNVAS CNRLLNLPSG PRSDCQRSPP 480
GVLKLNNSDS QDIRGQMRGS QNGPIASGHA PVIHSIQNLY PENFAPSFPH GSPGRYGAGG 540
RSEGGRSSRV SPAAAGYHSR AAKAKPPKQQ GAGDAEEEEE 580 |
Gene Ontology | GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045824; P:negative regulation of innate immune response; IMP:UniProtKB. GO:0034097; P:response to cytokine stimulus; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |