UniProt Accession

 TTPA_RAT; P41034 

Genbank Protein ID

 D16339 

Genbank Nucleotide ID

 BAA03843.1 

Protein Name

 Alpha-tocopherol transfer protein 

Protein Synonyms/Alias

 Alpha-TTP 

Gene Name

 Ttpa 

Gene Synonyms/Alias

 Tpp1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
178	ITPSVAKKIAAVVTD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). 

Sequence Annotation

 DOMAIN 88 253 CRAL-TRIO.
 BINDING 190 190 Phosphatidylinositol lipid headgroup (By
 BINDING 192 192 Phosphatidylinositol lipid headgroup (By
 BINDING 217 217 Phosphatidylinositol lipid headgroup (By
 BINDING 221 221 Phosphatidylinositol lipid headgroup (By  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Lipid-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 278 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005770; C:late endosome; IDA:RGD.
 GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; ISS:UniProtKB.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0008431; F:vitamin E binding; IDA:RGD.
 GO:0032502; P:developmental process; IEP:RGD.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0046909; P:intermembrane transport; ISS:UniProtKB.
 GO:0090212; P:negative regulation of establishment of blood-brain barrier; IEA:Compara.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0009268; P:response to pH; IDA:RGD.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0042360; P:vitamin E metabolic process; IDA:RGD.
 GO:0051180; P:vitamin transport; ISS:UniProtKB. 

Interpro

 IPR001071; CRAL-bd_toc_tran.
 IPR001251; CRAL-TRIO_dom.
 IPR011074; CRAL/TRIO_N_dom. 

Pfam

 PF00650; CRAL_TRIO
 PF03765; CRAL_TRIO_N 

SMART

 SM01100; CRAL_TRIO_N
 SM00516; SEC14 

PROSITE

 PS50191; CRAL_TRIO 

PRINTS

 PR00180; CRETINALDHBP.