CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026623
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysine--tRNA ligase 
Protein Synonyms/Alias
 Lysyl-tRNA synthetase 
Gene Name
 lysS 
Gene Synonyms/Alias
 RPA4685 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
167RFDATLLKVLERLEKacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131
Functional Description
  
Sequence Annotation
 MOTIF 50 58 "HIGH" region (By similarity).
 MOTIF 299 303 "KMSKS" region (By similarity).
 BINDING 302 302 ATP (By similarity).  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 545 AA 
Protein Sequence
MTTIDLPSAS ELRTLAEQSN AWPFEQARAL VNRLKKHPKD EVLFETGYGP SGLPHIGTFG 60
EVARTTMVRH AFRVLTDDKI KTKLLAFSDD MDGLRKVPDN VPNKELLEKN LGKSLTSVPD 120
PFGTHDSFGA HNNARLRAFL DTFGFDYEFA SATEYYKSGR FDATLLKVLE RLEKVMAIML 180
PSLREERAAS YSPFLPICPR TGVVLQVPIV AHDVKAGTIS YDDPETNERI TVPVTGGHCK 240
LQWKPDWAMR WTALGVDYEM AGKDLIDSVK LSGKIAQAIG GTPPEGFNYE LFLDDKGQKI 300
SKSKGNGLTI EEWLRYASPE SLSLFMYREP KAAKRLYFDV IPRNVDEYQQ FLDGYARQDL 360
KQRLANPVWH IHSGNPPQAD MPVTFQLLLT LVSSSNAENA DTLWGFIGRY RPGVTPQSHP 420
KLDAMVGYAI NYYRDFVAPT KVFRDPTDAE RAALQDLRDA LSQLPADATA EAIQDVVYEI 480
GRREPFLDHK KTAKDGKPGV SLDWFNMLYQ VLLGQEKGPR FGSFVAVYGV SNAVSMIDGA 540
LARSA 545 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004824; F:lysine-tRNA ligase activity; IEA:HAMAP.
 GO:0000049; F:tRNA binding; IEA:InterPro.
 GO:0006430; P:lysyl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR008925; aa-tRNA-synth_I_codon-bd.
 IPR020751; aa-tRNA-synth_I_codon-bd_sub2.
 IPR001412; aa-tRNA-synth_I_CS.
 IPR002904; Lys-tRNA-ligase.
 IPR014729; Rossmann-like_a/b/a_fold. 
Pfam
 PF01921; tRNA-synt_1f 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS