CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037488
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase Mer 
Protein Synonyms/Alias
  
Gene Name
 MERTK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
415RNLLILGKILGEGEFubiquitination[1]
589RIAKMPVKWIAIESLubiquitination[1, 2]
680VLRLQLEKLLESLPDubiquitination[1, 3, 4, 5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 823 AA 
Protein Sequence
MKINNEEIVS DPIYIEVQGL PHFTKQPESM NVTRNTAFNL TCQAVGPPEP VNIFWVQNSS 60
RVNEQPEKSP SVLTVPGLTE MAVFSCEAHN DKGLTVSKGV QINIKAIPSP PTEVSIRNST 120
AHSILISWVP GFDGYSPFRN CSIQVKEADP LSNGSVMIFN TSALPHLYQI KQLQALANYS 180
IGVSCMNEIG WSAVSPWILA STTEGAPSVA PLNVTVFLNE SSDNVDIRWM KPPTKQQDGE 240
LVGYRISHVW QSAGISKELL EEVGQNGSRA RISVQVHNAT CTVRIAAVTR GGVGPFSDPV 300
KIFIPAHGWV DYAPSSTPAP GNADPVLIIF GCFCGFILIG LILYISLAIR KRVQETKFGN 360
AFTEEDSELV VNYIAKKSFC RRAIELTLHS LGVSEELQNK LEDVVIDRNL LILGKILGEG 420
EFGSVMEGNL KQEDGTSLKV AVKTMKLDNS SQREIEEFLS EAACMKDFSH PNVIRLLGVC 480
IEMSSQGIPK PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLKFMVD IALGMEYLSN 540
RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW IAIESLADRV 600
YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL DELYEIMYSC 660
WRTDPLDRPT FSVLRLQLEK LLESLPDVRN QADVIYVNTQ LLESSEGLAQ GSTLAPLDLN 720
IDPDSIIASC TPRAAISVVT AEVHDSKPHE GRYILNGGSE EWEDLTSAPS AAVTAEKNSV 780
LPGERLVRNG VSWSHSSMLP LGSSLPDELL FADDSSEGSE VLM 823 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0001750; C:photoreceptor outer segment; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
 GO:0043277; P:apoptotic cell clearance; IEA:Compara.
 GO:0001779; P:natural killer cell differentiation; IEA:Compara.
 GO:0051250; P:negative regulation of lymphocyte activation; IEA:Compara.
 GO:0030168; P:platelet activation; IEA:Compara.
 GO:0043491; P:protein kinase B signaling cascade; IEA:Compara.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:0032940; P:secretion by cell; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Compara.
 GO:0060068; P:vagina development; IEA:Compara. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF00041; fn3
 PF07714; Pkinase_Tyr 
SMART
 SM00060; FN3
 SM00409; IG
 SM00219; TyrKc 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.