CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041596
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lymphoid enhancer binding factor 1, isoform CRA_a 
Protein Synonyms/Alias
 Lymphoid enhancer-binding factor 1 
Gene Name
 Lef1 
Gene Synonyms/Alias
 rCG_28787 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
84SQEPYHDKAREHPDDacetylation[1]
93REHPDDGKHPDGGLYacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 397 AA 
Protein Sequence
MPQLSGGGGG GDPELCATDE MIPFKDEGDP QKEKIFAEIS HPEEEGDLAD IKSSLVNESE 60
IIPASNGHEV VRQTQSSQEP YHDKAREHPD DGKHPDGGLY NKGPSYSSYS GYIMMPNMNS 120
DPYMSNGSLS PPIPRTSNKV PVVQPSHAVH PLTPLITYSD EHFSPGSHPS HIPSEVNPKQ 180
GMSRHPPAPE MPTFYPLSPG GVGQITPPLG WQGQPVYPIT GGFRQAYPSS LSGDTSMSRF 240
SHHMIPGPPG PHTTGIPHPA IVTPQVKQEH PHTDSDLMHV KPQHEQRKEQ EPKRPHIKKP 300
LNAFMLYMKE MRANVVAECT LKESAAINQI LGRRWHALSR EEQAKYYELA RKERQLHMQL 360
YPGWSARDNY GKKKKRKREK LQESTSGTGP RMTAAYI 397 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0032993; C:protein-DNA complex; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Compara.
 GO:0008301; F:DNA binding, bending; IEA:Compara.
 GO:0035326; F:enhancer binding; IEA:Compara.
 GO:0030284; F:estrogen receptor activity; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Compara.
 GO:0001228; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0060033; P:anatomical structure regression; IEA:Compara.
 GO:0060561; P:apoptotic process involved in morphogenesis; IEA:Compara.
 GO:0042100; P:B cell proliferation; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0060326; P:cell chemotaxis; IEA:Compara.
 GO:0071353; P:cellular response to interleukin-4; IEA:Compara.
 GO:0060710; P:chorio-allantoic fusion; IEA:Compara.
 GO:0021542; P:dentate gyrus development; IEA:Compara.
 GO:0030326; P:embryonic limb morphogenesis; IEA:Compara.
 GO:0001837; P:epithelial to mesenchymal transition; IEA:Compara.
 GO:0060325; P:face morphogenesis; IEA:Compara.
 GO:0021873; P:forebrain neuroblast division; IEA:Compara.
 GO:0021861; P:forebrain radial glial cell differentiation; IEA:Compara.
 GO:0021943; P:formation of radial glial scaffolds; IEA:Compara.
 GO:0043966; P:histone H3 acetylation; IEA:Compara.
 GO:0043967; P:histone H4 acetylation; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0030879; P:mammary gland development; IEA:Compara.
 GO:0071866; P:negative regulation of apoptotic process in bone marrow; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0022408; P:negative regulation of cell-cell adhesion; IEA:Compara.
 GO:0043392; P:negative regulation of DNA binding; IEA:Compara.
 GO:0071899; P:negative regulation of estrogen receptor binding; IEA:Compara.
 GO:0032696; P:negative regulation of interleukin-13 production; IEA:Compara.
 GO:0032713; P:negative regulation of interleukin-4 production; IEA:Compara.
 GO:0032714; P:negative regulation of interleukin-5 production; IEA:Compara.
 GO:0045843; P:negative regulation of striated muscle tissue development; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030223; P:neutrophil differentiation; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0001649; P:osteoblast differentiation; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0048341; P:paraxial mesoderm formation; IEA:Compara.
 GO:0001569; P:patterning of blood vessels; IEA:Compara.
 GO:0043923; P:positive regulation by host of viral transcription; IEA:Compara.
 GO:0090068; P:positive regulation of cell cycle process; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0071864; P:positive regulation of cell proliferation in bone marrow; IEA:Compara.
 GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Compara.
 GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Compara.
 GO:0030854; P:positive regulation of granulocyte differentiation; IEA:Compara.
 GO:0050909; P:sensory perception of taste; IEA:Compara.
 GO:0001756; P:somitogenesis; IEA:Compara.
 GO:0002040; P:sprouting angiogenesis; IEA:Compara.
 GO:0033153; P:T cell receptor V(D)J recombination; IEA:Compara.
 GO:0045063; P:T-helper 1 cell differentiation; IEA:Compara.
 GO:0043586; P:tongue development; IEA:Compara.
 GO:0061153; P:trachea gland development; IEA:Compara. 
Interpro
 IPR027397; Catenin_binding_dom.
 IPR013558; CTNNB1-bd_N.
 IPR009071; HMG_box_dom.
 IPR024940; TCF/LEF. 
Pfam
 PF08347; CTNNB1_binding
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS