CPLM-018650

Genbank Nucleotide ID

Protein Synonyms/Alias

Transferrin; Beta-1 metal-binding globulin; Siderophilin

Mus musculus (Mouse)

Position	Peptide	Type	References
696	LEACTFHKH******	acetylation	[1]
696	LEACTFHKH******	ubiquitination	[2]

[1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
[2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

DOMAIN 25 347 Transferrin-like 1.
DOMAIN 360 682 Transferrin-like 2.
METAL 82 82 Iron 1 (By similarity).
METAL 114 114 Iron 1 (By similarity).
METAL 207 207 Iron 1 (By similarity).
METAL 268 268 Iron 1 (By similarity).
METAL 410 410 Iron 2 (By similarity).
METAL 448 448 Iron 2 (By similarity).
METAL 537 537 Iron 2 (By similarity).
METAL 605 605 Iron 2 (By similarity).
BINDING 139 139 Carbonate 1 (By similarity).
BINDING 143 143 Carbonate 1 (By similarity).
BINDING 145 145 Carbonate 1; via amide nitrogen (By
BINDING 146 146 Carbonate 1; via amide nitrogen (By
BINDING 474 474 Carbonate 2 (By similarity).
BINDING 478 478 Carbonate 2 (By similarity).
BINDING 480 480 Carbonate 2; via amide nitrogen (By
BINDING 481 481 Carbonate 2; via amide nitrogen (By
MOD_RES 42 42 Omega-N-methylated arginine (By
CARBOHYD 513 513 N-linked (GlcNAc...).
DISULFID 28 67 By similarity.
DISULFID 38 58 By similarity.
DISULFID 137 213 By similarity.
DISULFID 156 350 By similarity.
DISULFID 177 193 By similarity.
DISULFID 180 196 By similarity.
DISULFID 190 198 By similarity.
DISULFID 246 260 By similarity.
DISULFID 363 395 By similarity.
DISULFID 373 386 By similarity.
DISULFID 420 692 By similarity.
DISULFID 435 655 By similarity.
DISULFID 472 543 By similarity.
DISULFID 496 683 By similarity.
DISULFID 506 520 By similarity.
DISULFID 517 526 By similarity.
DISULFID 583 597 By similarity.
DISULFID 633 638 By similarity.

Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Ion transport; Iron; Iron transport; Metal-binding; Methylation; Reference proteome; Repeat; Secreted; Signal; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005905; C:coated pit; IDA:MGI.
GO:0030139; C:endocytic vesicle; IDA:MGI.
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0055037; C:recycling endosome; IDA:MGI.
GO:0008199; F:ferric iron binding; IEA:InterPro.
GO:0007015; P:actin filament organization; IDA:DFLAT.
GO:0007257; P:activation of JUN kinase activity; IDA:DFLAT.
GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro.
GO:0070371; P:ERK1 and ERK2 cascade; IDA:DFLAT.
GO:0006826; P:iron ion transport; IMP:MGI.
GO:0030316; P:osteoclast differentiation; IDA:DFLAT.
GO:0045780; P:positive regulation of bone resorption; IDA:DFLAT.
GO:2000147; P:positive regulation of cell motility; IDA:DFLAT.
GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:DFLAT.
GO:0060395; P:SMAD protein signal transduction; IDA:MGI.

IPR016357; Transferrin.
IPR001156; Transferrin_fam.
IPR018195; Transferrin_Fe_BS.

PF00405; Transferrin

PS00205; TRANSFERRIN_LIKE_1
PS00206; TRANSFERRIN_LIKE_2
PS00207; TRANSFERRIN_LIKE_3
PS51408; TRANSFERRIN_LIKE_4

PR00422; TRANSFERRIN.