UniProt Accession

 RGS1_HUMAN; Q08116; B2RDM9; B4DZY0; Q07918; Q9H1W2 

Genbank Protein ID

 AK303138; AK315607; AL136987; BC015510; S59049; X73427; AF493925; BT006668 

Genbank Nucleotide ID

 BAG64242.1; BAG37976.1; CAC19805.1; AAH15510.1; AAB26289.1; CAA51826.1; AAM12639.1; AAP35314.1 

Protein Name

 Regulator of G-protein signaling 1 

Protein Synonyms/Alias

 RGS1; B-cell activation protein BL34; Early response protein 1R20 

Gene Name

 RGS1 

Gene Synonyms/Alias

 1R20; BL34; IER1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	ISTPKLDKMPGMFFS	methylation	[1]
24	MFFSANPKELKGTTH	methylation	[1]
164	ESTAKKIKAPTPTCF	methylation	[1]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 

Sequence Annotation

 DOMAIN 85 200 RGS.
 MOD_RES 32 32 Phosphoserine; by CK2 (Potential).
 MOD_RES 67 67 Phosphoserine; by PKC (Potential).
 MOD_RES 75 75 Phosphoserine; by CK2 (Potential).
 MOD_RES 159 159 Phosphothreonine; by PKC (Potential).
 MOD_RES 169 169 Phosphothreonine; by CK2 (Potential).
 MOD_RES 180 180 Phosphothreonine; by CK2 (Potential).
 MOD_RES 207 207 Phosphoserine; by PKC (Potential).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Signal transduction inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0005516; F:calmodulin binding; TAS:ProtInc.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam. 

Pfam

 PF00615; RGS 

SMART

 SM00315; RGS 

PROSITE

 PS50132; RGS 

PRINTS

 PR01301; RGSPROTEIN.