CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009995
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysosomal alpha-glucosidase 
Protein Synonyms/Alias
 Acid maltase 
Gene Name
 Gaa 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
895NKLVRVTKEGAELQLacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Essential for the degradation of glygogen to glucose in lysosomes. 
Sequence Annotation
 DOMAIN 80 131 P-type.
 ACT_SITE 518 518 Nucleophile (By similarity).
 ACT_SITE 521 521 By similarity.
 CARBOHYD 140 140 N-linked (GlcNAc...).
 CARBOHYD 233 233 N-linked (GlcNAc...) (Potential).
 CARBOHYD 390 390 N-linked (GlcNAc...) (Potential).
 CARBOHYD 470 470 N-linked (GlcNAc...).
 CARBOHYD 883 883 N-linked (GlcNAc...) (Potential).
 CARBOHYD 926 926 N-linked (GlcNAc...) (Potential).
 CARBOHYD 933 933 N-linked (GlcNAc...) (Potential).
 DISULFID 82 109 By similarity.
 DISULFID 92 108 By similarity.
 DISULFID 103 127 By similarity.  
Keyword
 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Membrane; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 953 AA 
Protein Sequence
MNIRKPLCSN SVVGACTLIS LTTAVILGHL MLRELMLLPQ DLHESSSGLW KTYRPHHQEG 60
YKPGPLHIQE QTEQPKEAPT QCDVPPSSRF DCAPDKGISQ EQCEARGCCY VPAGQVLKEP 120
QIGQPWCFFP PSYPSYRLEN LSSTESGYTA TLTRTSPTFF PKDVLTLQLE VLMETDSRLH 180
FKIKDPASKR YEVPLETPRV LSQAPSPLYS VEFSEEPFGV IVRRKLGGRV LLNTTVAPLF 240
FADQFLQLST SLPSQHITGL GEHLSPLMLS TDWARITLWN RDTPPSQGTN LYGSHPFYLA 300
LEDGGLAHGV FLLNSNAMDV ILQPSPALTW RSTGGILDVY VFLGPEPKSV VQQYLDVVGY 360
PFMPPYWGLG FHLCRWGYSS TAIVRQVVEN MTRTHFPLDV QWNDLDYMDA RRDFTFNQDS 420
FADFPDMVRE LHQDGRRYMM IVDPAISSAG PAGSYRPYDE GLRRGVFITN ETGQPLIGKV 480
WPGTTAFPDF TNPETLDWWQ DMVSEFHAQV PFDGMWLDMN EPSNFVRGSQ QGCPNNELEN 540
PPYVPGVVGG ILQAATICAS SHQFLSTHYN LHNLYGLTEA IASSRALVKT RGTRPFVISR 600
STFSGHGRYA GHWTGDVRSS WEHLAYSVPD ILQFNLLGVP LVGADICGFI GDTSEELCVR 660
WTQLGAFYPF MRNHNDLNSV PQEPYRFSET AQQAMRKAFA LRYALLPYLY TLFHRAHVRG 720
DTVARPLFLE FPEDPSTWSV DRQLLWGPAL LITPVLEPGK TEVTGYFPKG TWYNMQMVSV 780
DSLGTLPSPS SASSFRSAVQ SKGQWLTLEA PLDTINVHLR EGYIIPLQGP SLTTTESRKQ 840
PMALAVALTA SGEADGELFW DDGESLAVLE RGAYTLVTFS AKNNTIVNKL VRVTKEGAEL 900
QLREVTVLGV ATAPTQVLSN GIPVSNFTYS PDNKSLAIPV SLLMGELFQI SWS 953 
Gene Ontology
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IMP:MGI.
 GO:0004558; F:alpha-glucosidase activity; IDA:MGI.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0032450; F:maltose alpha-glucosidase activity; IEA:EC.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0002086; P:diaphragm contraction; IMP:MGI.
 GO:0005980; P:glycogen catabolic process; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0007040; P:lysosome organization; IMP:MGI.
 GO:0046716; P:muscle cell homeostasis; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0050884; P:neuromuscular process controlling posture; IMP:MGI.
 GO:0002026; P:regulation of the force of heart contraction; IMP:MGI.
 GO:0009888; P:tissue development; IMP:MGI.
 GO:0043587; P:tongue morphogenesis; IEA:Compara.
 GO:0043181; P:vacuolar sequestering; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 
Interpro
 IPR011013; Gal_mutarotase_SF_dom.
 IPR000322; Glyco_hydro_31.
 IPR025887; Glyco_hydro_31_N_dom.
 IPR017853; Glycoside_hydrolase_SF.
 IPR000519; P_trefoil.
 IPR017957; P_trefoil_CS. 
Pfam
 PF13802; Gal_mutarotas_2
 PF01055; Glyco_hydro_31
 PF00088; Trefoil 
SMART
 SM00018; PD 
PROSITE
 PS00129; GLYCOSYL_HYDROL_F31_1
 PS00707; GLYCOSYL_HYDROL_F31_2
 PS00025; P_TREFOIL_1
 PS51448; P_TREFOIL_2 
PRINTS