| Tag | Content |
|---|
| CPLM ID | CPLM-014417 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tyrosine-protein kinase Srms |
Protein Synonyms/Alias | PTK70 |
Gene Name | Srms |
Gene Synonyms/Alias | Srm |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 265 | PVAVKVIKSADMKLA | acetylation | [1] |
|
Reference | [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y. Mol Cell. 2006 Aug;23(4):607-18. [ PMID: 16916647] |
Functional Description | May be involved in proliferation or differentiation of keratinocytes in the skin. |
Sequence Annotation | DOMAIN 55 116 SH3.
DOMAIN 124 216 SH2.
DOMAIN 234 495 Protein kinase.
NP_BIND 240 248 ATP (By similarity).
ACT_SITE 354 354 Proton acceptor (By similarity).
BINDING 262 262 ATP (By similarity).
MOD_RES 265 265 N6-acetyllysine.
MOD_RES 384 384 Phosphotyrosine; by autocatalysis (By |
Keyword | Acetylation; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 496 AA |
Protein Sequence | MEPFLRKRLT FLSFFWDKIW PADESEEDIP RIQGHDDNPV PEQAAAVEPC SFPAPRARLF 60
RALYDFTARC AEELSVSRGD RLYALKEEGD YIFAQRLSGP PSTGLVPVTY LAKATPEPPS 120
DQPWYFSGIS RAQAQQLLLS PANAPGAFLI RPSESSIGGY SLSVRAQAKV CHYRICMAPS 180
GSLYLQEGQL FPSLDALLAY YKTNWKLIQN PLLQPCIPQI PLVQDEWERP RSEFVLRRKL 240
GEGFFGEVWE GLWLGSIPVA VKVIKSADMK LADLTKEIEA LKSLRHERLI RLHAICSLGE 300
PVYIVTELMG KGNLQVYLGS SEGKALSLPH LLGFACQVAE GMSYLEERRV VHRDLAARNV 360
LVGDDLTCKV ADFGLARLLK DDVYSPSSGS KIPVKWTAPE AANYRVFSQK SDVWSFGILL 420
YEVFTYGQCP YEGMTNHETL QQISRGYRLP RPAVCPAEVY VLMVECWKGS PEERPTFAIL 480
REKLNAINRR LHLGLT 496 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. |
Interpro | |
Pfam | |
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