UniProt Accession

 GBRB1_HUMAN; P18505; B2R6U7; Q16166; Q8TBK3 

Genbank Protein ID

 X14767; M59216; M59212; M59214; M59215; AK312720; CH471069; BC022449; S70733 

Genbank Nucleotide ID

 CAA32875.1; AAA35862.1; AAA35862.1; AAA35862.1; AAA35862.1; BAG35594.1; EAW93031.1; AAH22449.1; AAB30712.1 

Protein Name

 Gamma-aminobutyric acid receptor subunit beta-1 

Protein Synonyms/Alias

 GABA(A) receptor subunit beta-1 

Gene Name

 GABRB1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	DTYFLNDKKSFVHGV	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 

Sequence Annotation

 CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
 CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
 DISULFID 161 175 By similarity.  

Keyword

 Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Polymorphism; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 474 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005635; C:nuclear envelope; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0043235; C:receptor complex; IEA:Compara.
 GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
 GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
 GO:0004890; F:GABA-A receptor activity; TAS:ProtInc.
 GO:0021954; P:central nervous system neuron development; IEA:Compara.
 GO:0034220; P:ion transmembrane transport; TAS:Reactome.
 GO:0042698; P:ovulation cycle; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR006028; GABAA_rcpt.
 IPR002289; GABAAb_rcpt.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 

Pfam

 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 

SMART

  

PROSITE

 PS00236; NEUROTR_ION_CHANNEL 

PRINTS

 PR01160; GABAARBETA.
 PR00253; GABAARECEPTR.
 PR00252; NRIONCHANNEL.