CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006678
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bone morphogenetic protein receptor type-1A 
Protein Synonyms/Alias
 BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; ALK-3; BMP-2/BMP-4 receptor; Serine/threonine-protein kinase receptor R5; SKR5; CD292 
Gene Name
 Bmpr1a 
Gene Synonyms/Alias
 Acvrlk3; Bmpr 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
232LVQRTIAKQIQMVRQubiquitination[1]
523RIKKTLAKMVESQDVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. 
Sequence Annotation
 DOMAIN 204 233 GS.
 DOMAIN 234 525 Protein kinase.
 NP_BIND 240 248 ATP (By similarity).
 REGION 107 109 Mediates specificity for BMP ligand (By
 ACT_SITE 362 362 Proton acceptor (By similarity).
 BINDING 261 261 ATP (By similarity).
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 DISULFID 61 82 By similarity.
 DISULFID 63 67 By similarity.
 DISULFID 76 100 By similarity.
 DISULFID 110 124 By similarity.
 DISULFID 125 130 By similarity.  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 532 AA 
Protein Sequence
MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL APEDTLPFLK 60
CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 120
TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVVLISM AVCIVAMIIF SSCFCYKHYC 180
KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240
GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360
RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTKRYMAP EVLDESLNKN 420
HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 480
PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532 
Gene Ontology
 GO:0005901; C:caveola; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI.
 GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro.
 GO:0030509; P:BMP signaling pathway; IDA:MGI.
 GO:0051216; P:cartilage development; IMP:MGI.
 GO:0048589; P:developmental growth; IMP:MGI.
 GO:0009950; P:dorsal/ventral axis specification; IMP:MGI.
 GO:0007398; P:ectoderm development; IMP:MGI.
 GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
 GO:0048568; P:embryonic organ development; IMP:MGI.
 GO:0003272; P:endocardial cushion formation; IMP:MGI.
 GO:0060914; P:heart formation; IMP:MGI.
 GO:0035137; P:hindlimb morphogenesis; IMP:MGI.
 GO:0006955; P:immune response; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0048368; P:lateral mesoderm development; IMP:MGI.
 GO:0030324; P:lung development; IMP:MGI.
 GO:0048382; P:mesendoderm development; IMP:MGI.
 GO:0001707; P:mesoderm formation; IMP:MGI.
 GO:0001880; P:Mullerian duct regression; IMP:MGI.
 GO:0050768; P:negative regulation of neurogenesis; IMP:MGI.
 GO:0014032; P:neural crest cell development; IMP:MGI.
 GO:0021998; P:neural plate mediolateral regionalization; IMP:MGI.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
 GO:0060021; P:palate development; IMP:MGI.
 GO:0048352; P:paraxial mesoderm structural organization; IMP:MGI.
 GO:0021983; P:pituitary gland development; IMP:MGI.
 GO:0030501; P:positive regulation of bone mineralization; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:MGI.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Compara.
 GO:0060391; P:positive regulation of SMAD protein import into nucleus; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0048378; P:regulation of lateral mesodermal cell fate specification; IGI:MGI.
 GO:0001756; P:somitogenesis; IMP:MGI.
 GO:0019827; P:stem cell maintenance; IMP:MGI. 
Interpro
 IPR000472; Activin_rcpt.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS.
 IPR003605; TGF_beta_rcpt_GS. 
Pfam
 PF01064; Activin_recp
 PF00069; Pkinase
 PF08515; TGF_beta_GS 
SMART
 SM00467; GS 
PROSITE
 PS51256; GS
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS