CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042262
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Adenosylhomocysteinase 
Protein Synonyms/Alias
  
Gene Name
 LOC100723355 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
43REMYSASKPLKGARIacetylation[1]
166TGVHNLYKMMAKGILacetylation[1]
170NLYKMMAKGILKVPAacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019
Functional Description
  
Sequence Annotation
 BINDING 57 57 Substrate (By similarity).
 BINDING 131 131 Substrate (By similarity).
 BINDING 156 156 Substrate (By similarity).
 BINDING 186 186 Substrate (By similarity).
 BINDING 190 190 Substrate (By similarity).  
Keyword
 Complete proteome; Hydrolase; NAD; One-carbon metabolism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 432 AA 
Protein Sequence
SQDSHLAFTA DISLAAWGRK ALDIAENEMP GLMRMREMYS ASKPLKGARI AGCLHMTVET 60
AVLIETLVAL GAEVQWSSCN IFSTQDHAAA AIAKAGIPVY AWKGETDEEY LWCIEQTLYF 120
KDGPLNMILD DGGDLTNLIH TKYPQLLSGI RGISEETTTG VHNLYKMMAK GILKVPAINV 180
NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVAVVAG YGDVGKGCAQ ALRGFGARVI 240
ITEIDPINAL QAAMEGYEVT TMDEACQEGN IFVTTTGCVD IILGRHFEQM KDDAIVCNIG 300
HFDVEIDVKW LNENAVEKVN IKPQVDRYRL KNGHRIILLA EGRLVNLGCA MGHPSFVMSN 360
SFTNQVLAQI ELWTHAEKYP VGVHFLPKKL DEAVAAAHLG KLNVKLTKLT DKQAKYLGLP 420
SDGPFKADHY RY 432 
Gene Ontology
 GO:0004013; F:adenosylhomocysteinase activity; IEA:EC.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR000043; Adenosylhomocysteinase.
 IPR015878; Ado_hCys_hydrolase_NAD-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR020082; S-Ado-L-homoCys_hydrolase_CS. 
Pfam
 PF05221; AdoHcyase
 PF00670; AdoHcyase_NAD 
SMART
 SM00996; AdoHcyase
 SM00997; AdoHcyase_NAD 
PROSITE
 PS00738; ADOHCYASE_1
 PS00739; ADOHCYASE_2 
PRINTS