CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006004
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium- and chloride-dependent GABA transporter 3 
Protein Synonyms/Alias
 GAT-3; Sodium- and chloride-dependent GABA transporter 4; GAT-4; Solute carrier family 6 member 11 
Gene Name
 Slc6a11 
Gene Synonyms/Alias
 Gabt3; Gabt4; Gat-4; Gat3; Gat4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
13ALPLGNGKAAEEARGubiquitination[1]
581TLPEKLQKLTVPSADubiquitination[1]
590TVPSADLKMRGKLGAubiquitination[1]
610TVNDCEAKVKGDGTIubiquitination[1]
612NDCEAKVKGDGTISAubiquitination[1]
623TISAITEKETHF***ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine. 
Sequence Annotation
 CARBOHYD 182 182 N-linked (GlcNAc...) (Potential).
 CARBOHYD 185 185 N-linked (GlcNAc...) (Potential).
 CARBOHYD 193 193 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Neurotransmitter transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 627 AA 
Protein Sequence
MTAEQALPLG NGKAAEEARG SETLGGGGGG AAGTREARDK AVHERGHWNN KVEFVLSVAG 60
EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF LETALGQFTS EGGITCWRRV 120
CPLFEGIGYA TQVIEAHLNV YYIIILAWAI FYLSNCFTTE LPWATCGHEW NTEKCVEFQK 180
LNFSNYSHVS LQNATSPVME FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK 240
GTKSTGKVVY VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ 300
IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV LGFMAYEQGV 360
PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF LGLDSQFVCV ESLVTAVVDM 420
YPKVFRRGYR RELLILALSI ISYFLGLVML TEGGMYIFQL FDSYAASGMC LLFVAIFECV 480
CIGWVYGSNR FYDNIEDMIG YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT 540
YPAWGYGIGW LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR 600
TVTVNDCEAK VKGDGTISAI TEKETHF 627 
Gene Ontology
 GO:0042995; C:cell projection; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005332; F:gamma-aminobutyric acid:sodium symporter activity; IEA:Compara.
 GO:0042165; F:neurotransmitter binding; IEA:Compara.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002982; Na/ntran_symport_GABA_GAT3. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR01197; GAT3TRNSPORT.
 PR00176; NANEUSMPORT.