CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015207
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Basic leucine zipper and W2 domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 Bzw1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
140KKLLLFLKGFSESERubiquitination[1]
379LSEEPILKWYKDAHVubiquitination[1]
399VFLEQMKKFVEWLKNubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity). 
Sequence Annotation
 DOMAIN 247 414 W2.
 MOD_RES 411 411 Phosphoserine (By similarity).
 MOD_RES 413 413 Phosphoserine (By similarity).  
Keyword
 Activator; Complete proteome; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 419 AA 
Protein Sequence
MNNQKQQKPT LSGQRFKTRK RDEKERFDPT QFQDCIIQGL TETGTDLEAV AKFLDASGAK 60
LDYRRYAETL FDILVAGGML APGGTLADDM MRTDVCVFAA QEDLETMQAF AQVFNKLIRR 120
YKYLEKGFED EVKKLLLFLK GFSESERNKL AMLTGVLLAN GTLNASILNS LYNENLVKEG 180
VSAAFAVKLF KSWINEKDIN AVAASLRKVS MDNRLMELFP ANKQSVEHFT KYFTEAGLKE 240
LSEYVRNQQT IGARKELQKE LQEQMSRGDP FKDIILYVKE EMKKNNIPEP VVIGIVWSSV 300
MSTVEWNKKE ELVAEQAIKH LKQYSPLLAA FTTQGQSELT LLLKIQEYCY DNIHFMKAFQ 360
KIVVLFYKAE VLSEEPILKW YKDAHVAKGK SVFLEQMKKF VEWLKNAEEE SESEAEEGD 419 
Gene Ontology
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR016024; ARM-type_fold.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003307; W2_domain. 
Pfam
 PF02020; W2 
SMART
 SM00515; eIF5C 
PROSITE
 PS51363; W2 
PRINTS