UniProt Accession

 B2ZWH1_HUMAN; B2ZWH1 

Genbank Protein ID

 Z99127 

Genbank Nucleotide ID

  

Protein Name

 Calcyclin-binding protein 

Protein Synonyms/Alias

  

Gene Name

 CACYBP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MASEELQKDLEEVKV	acetylation	[1]
8	MASEELQKDLEEVKV	ubiquitination	[2]
14	QKDLEEVKVLLEKAT	acetylation	[3]
14	QKDLEEVKVLLEKAT	ubiquitination	[2, 4]
19	EVKVLLEKATRKRVR	acetylation	[3]
19	EVKVLLEKATRKRVR	ubiquitination	[1, 2]
33	RDALTAEKSKIETEI	acetylation	[1, 3]
33	RDALTAEKSKIETEI	ubiquitination	[5]
41	SKIETEIKNKMQQKS	acetylation	[6]
41	SKIETEIKNKMQQKS	ubiquitination	[1, 2]
43	IETEIKNKMQQKSQK	ubiquitination	[2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 50 AA 

Protein Sequence

Gene Ontology

 GO:0044297; C:cell body; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005641; C:nuclear envelope lumen; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0071277; P:cellular response to calcium ion; IEA:Compara.
 GO:0060548; P:negative regulation of cell death; IEA:Compara.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0060416; P:response to growth hormone stimulus; IEA:Compara. 

Interpro

 IPR015120; Siah-Interact_N. 

Pfam

 PF09032; Siah-Interact_N 

SMART

  

PROSITE

  

PRINTS