CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007979
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60S ribosomal protein L5 
Protein Synonyms/Alias
  
Gene Name
 Rpl5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
5***MGFVKVVKNKAYacetylation[1, 2]
41KRLVIQDKNKYNTPKacetylation[3]
43LVIQDKNKYNTPKYRacetylation[1]
164NKVFGALKGAVDGGLubiquitination[4]
220EEDEDAYKKQFSQYIacetylation[1, 2, 3]
220EEDEDAYKKQFSQYIsuccinylation[3]
228KQFSQYIKNNVTPDMubiquitination[4]
241DMMEEMYKKAHAAIRacetylation[1, 2]
255RENPVYEKKPKREVKacetylation[1]
283KKDRVAQKKASFLRAacetylation[2]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for rRNA maturation and formation of the 60S ribosomal subunits (By similarity). This protein binds 5S RNA. 
Sequence Annotation
 MOD_RES 5 5 N6-acetyllysine (By similarity).
 MOD_RES 48 48 N6-acetyllysine (By similarity).
 MOD_RES 272 272 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 297 AA 
Protein Sequence
MGFVKVVKNK AYFKRYQVRF RRRREGKTDY YARKRLVIQD KNKYNTPKYR MIVRVTNRDI 60
ICQIAYARIE GDMIVCAAYA HELPKYGVKV GLTNYAAAYC TGLLLARRLL NRFGMDKIYE 120
GQVEVNGGEY NVESIDGQPG AFTCYLDAGL ARTTTGNKVF GALKGAVDGG LSIPHSTKRF 180
PGYDSESKEF NAEVHRKHIM GQNVADYMRY LMEEDEDAYK KQFSQYIKNN VTPDMMEEMY 240
KKAHAAIREN PVYEKKPKRE VKKKRWNRPK MSLAQKKDRV AQKKASFLRA QERAAES 297 
Gene Ontology
 GO:0022625; C:cytosolic large ribosomal subunit; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; ISO:MGI.
 GO:0008097; F:5S rRNA binding; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0042273; P:ribosomal large subunit biogenesis; IEA:Compara.
 GO:0006364; P:rRNA processing; IEA:Compara.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR005485; Rbsml_L5_euk/L18_arc.
 IPR025607; Rbsml_L5e/L18P_C.
 IPR005484; Ribosomal_L18/L5. 
Pfam
 PF14204; Ribosomal_L18_c
 PF00861; Ribosomal_L18p 
SMART
  
PROSITE
  
PRINTS
 PR00058; RIBOSOMALL5.