UniProt Accession

 MORC3_HUMAN; Q14149; A8KA92; Q9UEZ2 

Genbank Protein ID

 D50926; AK292957; AP000693; AP000692 

Genbank Nucleotide ID

 BAA09485.2; BAF85646.1; BAA89432.1; BAA89432.1 

Protein Name

 MORC family CW-type zinc finger protein 3 

Protein Synonyms/Alias

 Zinc finger CW-type coiled-coil domain protein 3 

Gene Name

 MORC3 

Gene Synonyms/Alias

 KIAA0136; ZCWCC3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
79	MTSDKLHKMLSFGFS	ubiquitination	[1]
105	GLYGNGFKSGSMRLG	ubiquitination	[1]
152	VPIVAFNKHRQMINL	ubiquitination	[1]
192	LDAIIGKKGTRIIIW	ubiquitination	[1]
214	ATEFDFEKDKYDIRI	ubiquitination	[1]
216	EFDFEKDKYDIRIPE	ubiquitination	[1]
231	DLDEITGKKGYKKQE	ubiquitination	[1, 2]
232	LDEITGKKGYKKQER	ubiquitination	[1, 2]
261	YCSILYLKPRMQIIL	ubiquitination	[1]
274	ILRGQKVKTQLVSKS	ubiquitination	[1]
280	VKTQLVSKSLAYIER	ubiquitination	[1, 3, 4]
293	ERDVYRPKFLSKTVR	ubiquitination	[1, 3]
297	YRPKFLSKTVRITFG	ubiquitination	[1, 4]
310	FGFNCRNKDHYGIMM	ubiquitination	[1]
325	YHRNRLIKAYEKVGC	ubiquitination	[1]
329	RLIKAYEKVGCQLRA	ubiquitination	[1]
353	IIECNFLKPTHNKQD	ubiquitination	[1]
358	FLKPTHNKQDFDYTN	ubiquitination	[1]
377	TITALGEKLNDYWNE	ubiquitination	[1, 2]
386	NDYWNEMKVKKNTEY	ubiquitination	[1]
388	YWNEMKVKKNTEYPL	ubiquitination	[1]
389	WNEMKVKKNTEYPLN	ubiquitination	[1, 2, 4]
404	LPVEDIQKRPDQTWV	ubiquitination	[1]
432	GMDQLPEKWYCSNNP	ubiquitination	[1, 5]
464	LVHPTYEKTYKKTNK	ubiquitination	[1]
468	TYEKTYKKTNKEKFR	ubiquitination	[1]
687	ETQETTDKSADDAGC	ubiquitination	[2]
710	LLLVTEEKENYKRQC	ubiquitination	[3]
762	LLESINGKSESPDHM	ubiquitination	[6]
806	QCSNNESKSEMDEMA	ubiquitination	[2]
825	DVFRQLDKCSIERDQ	ubiquitination	[1, 2, 3, 7, 8]
834	SIERDQYKSEVELLE	ubiquitination	[2]
844	VELLEMEKSQIRSQC	ubiquitination	[1, 2, 9]
862	KTEVEQLKSTNQQTA	ubiquitination	[2, 9]
891	HMDGESLKLRSLRVN	ubiquitination	[1, 2, 3, 8, 9, 10]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [8] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [9] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [10] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

  

Sequence Annotation

 ZN_FING 404 454 CW-type.
 MOD_RES 503 503 Phosphoserine.  

Keyword

 Coiled coil; Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 939 AA 

Protein Sequence

Gene Ontology

 GO:0016235; C:aggresome; IDA:HPA.
 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0016605; C:PML body; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007569; P:cell aging; IDA:MGI.
 GO:0051457; P:maintenance of protein location in nucleus; IDA:MGI.
 GO:0048147; P:negative regulation of fibroblast proliferation; IDA:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0050821; P:protein stabilization; IDA:MGI. 

Interpro

 IPR003594; HATPase_ATP-bd.
 IPR011124; Znf_CW. 

Pfam

 PF07496; zf-CW 

SMART

  

PROSITE

 PS51050; ZF_CW 

PRINTS