Tag | Content |
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CPLM ID | CPLM-024779 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Activating signal cointegrator 1 complex subunit 3 |
Protein Synonyms/Alias | |
Gene Name | Ascc3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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573 | TGDMQLSKSEILRTQ | acetylation | [1] | 1145 | ILTRLEEKNLTVDKL | acetylation | [1] | 1400 | WKIRIEEKLGKKVIE | acetylation | [1] | 1403 | RIEEKLGKKVIELTG | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation (By similarity). |
Sequence Annotation | DOMAIN 487 670 Helicase ATP-binding 1. DOMAIN 697 915 Helicase C-terminal 1. DOMAIN 979 1288 SEC63 1. DOMAIN 1337 1512 Helicase ATP-binding 2. DOMAIN 1565 1739 Helicase C-terminal 2. DOMAIN 1812 2175 SEC63 2. NP_BIND 500 507 ATP (By similarity). NP_BIND 1350 1357 ATP (By similarity). MOTIF 612 615 DEVH box. MOTIF 1454 1457 DEIH box. MOD_RES 573 573 N6-acetyllysine (By similarity). |
Keyword | Acetylation; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; DNA damage; DNA repair; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2197 AA |
Protein Sequence | MALPRLTGAL RSFSNVTKQD NYNEEVADLK LKRSKLHEQA LDFGLSWKKI VKFLNEKLEK 60 NKMQTINEDL KDILQAAKQI VGTDNGNEAI ESGAAFLFMT FHMTDSVGYT ETKAIRQMFG 120 PFPSSSATSA CNATSRIISH FSQDDLTALV QATENQCNDR VVFGRNLAFS FDMHDLDHFD 180 ELPVNGEAQK TISLDYKKFL NEQFQEPYTP ELKPVEKSNG SLLWCEVEKY LNATLKEMTE 240 APRVEDLCCT LYDMLASAKS GDELQDELFE LLGPGGLDLI EKLLQNRITI VDRFLNSSSD 300 HKFQVLQDNC KKILGENAKP NYGCQVTIQS EQEKQLMKQY RREEKRIARR EKKAGEDGEV 360 SGEGLLPFDP KELRLQREHA LLNARSAPIL GRQRDTEVEK IRYPHVYDSQ AAARETSAFI 420 AGAKMILPEG IQRENTKLYE EVRIPYSEPM PVGFEEKPVY IQDLDEVGQL AFKGMKRLNR 480 IQSIVFDTAY NTNENMLICA PTGAGKTNIA MLTVLHEIRQ HFHQGVLKKN EFKIVYVAPM 540 KALAAEMTNY FSKRLEPLGI VVKELTGDMQ LSKSEILRTQ MLVTTPEKWD VVTRKSVGDV 600 ALSQIVKLLI LDEVHLLHED RGPVLESIVA RTLRQVESTQ SMIRILGLSA TLPNYLDVAT 660 FLHVNPYIGL FYFDGRFRPV PLGQTFLGIK SANKMQQLNN MDEVCYESVL KQVKAGHQVM 720 VFVHARNATV RTAMSLIERA KNSGQISCFL PTQGPEYGHA LKQVQKSRNK QVRELFSDGF 780 SIHHAGMLRQ DRNLVENLFS NGHIKVLVCT ATLAWGVNLP AHAVIIKGTQ IYAAKRGSFV 840 DLGILDVMQI FGRAGRPQFD KFGEGIIITT HDKLSHYLSL LTQQNPIESQ FLESLADNLN 900 AEIALGTVTN VEEAVKWMSY TYLYVRMRAN PLAYGISHKA YQMDPTLRKH REQLLIEVGQ 960 KLDKARMIRF EERTGYFSST DLGRTASHYY IKYNTIETFN ELFDAHKTEG DIFAIVSKAE 1020 EFDQIKVREE EIEELDALLN NFCELSAPGG VENSYGKINI LLQTYISRGE MDSFSLISDS 1080 AYVAQNAARI VRALFEIALR KRWPTMTYRL LNLSKVIDKR LWGWASPLRQ FSVLPPHILT 1140 RLEEKNLTVD KLKDMRKDEI GHILHHVNIG LKVKQCVHQI PSVTMEASIQ PITRTVLRVS 1200 LNIYPDFSWN DQVHGTVGEP WWIWVEDPTN DHIYHSEYFL ALKKQVINKE AQLLVFTIPI 1260 FEPLPSQYYI RAVSDRWLGA EAVCIINFQH LILPERHPPH TELLDLQPLP VTALGCKAYE 1320 ALYNFSHFNP VQTQIFHTLY HTDCNVLLGA PTGSGKTVAA ELAIFRVFNK YPTSKAVYIA 1380 PLKALVRERM DDWKIRIEEK LGKKVIELTG DVTPDMKSIA KADLIVTTPE KWDGVSRSWQ 1440 NRSYVQQVNI LIIDEIHLLG EERGPVLEVI VSRTNFISSH TEKPVRIVGL STALANARDL 1500 ADWLNIKQMG LFNFRPSVRP VPLEVHIQGF PGQHYCPRMA SMNKPAFQES HTHCPDRPCL 1560 LLPERMLSSM TKLELIAFLA TEEDPKQWLN MDEQEMENII ATVRDSNLKL TLAFGIGMHH 1620 AGLHERDRKT VEELFVNCKV QVLIATSTLA WGVNFPAHLV IIKGTEYYDG KTRRYVDFPI 1680 TDVLQMMGRA GRPQFDDQGK AVILVHDIKK DFYKKFLYEP FPVESSLLGV LSDHLNAEIA 1740 GGTITSKQDA LDYITWTYFF RRLIMNPSYY NLGDVSQDAI NKFLSHLIGQ SLVELELSHC 1800 IEVGEDNRSI EPLTCGRIAS YYYLKHKTVK MFKDRLKPEC STEELLSILS DAEEYTDLPV 1860 RHNEDHTNNE LAKCLPIELN PHSFDSPHTK AHLLLQAHLS RAMLPCPDYD TDTKTVLDQA 1920 LRVCQAMLDV AASQGWLVTT LNITHLIQMV IQGRWLKDSS LLTIPNIEQH HLHLFRKWKP 1980 PVKGPHAKCR TSIECLPELI HACEGKEHVF SSMVEKELQP AKTKQAWNFL SHLPVINVGI 2040 SVKGSWDDSV EGHNELSIST LTADKRDENT WIKLHADQQY VLQVSLQRVH FEFHKVKHES 2100 HAVTPRFPKL KDEGWFLILG EVDKRELVAV KRVGFVRTHH EASISFFTPE APGRYIFTLY 2160 LMSDCYLGLD QQYDIFLNVT KADISTQINT EVPDVST 2197 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; ISS:UniProtKB. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0008283; P:cell proliferation; ISS:UniProtKB. GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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