CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000276
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RANBP2-like and GRIP domain-containing protein 8 
Protein Synonyms/Alias
 Ran-binding protein 2-like 3; RanBP2-like 3; RanBP2L3 
Gene Name
 RGPD8 
Gene Synonyms/Alias
 RANBP2ALPHA; RANBP2L1; RANBP2L3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
28SPRQKSMKGFYFAKLubiquitination[1]
182YRSTKRLKDAVAHCHubiquitination[1]
733DSNLSVVKKLPVPLEubiquitination[1]
1085ERGLGNLKILKNEVNubiquitination[2]
1382ERGIGDIKILQNYDNubiquitination[2]
1390ILQNYDNKQVRIVMRubiquitination[1]
1448EHLAVRFKLQDVADSubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
 REPEAT 26 59 TPR 1.
 REPEAT 60 93 TPR 2.
 REPEAT 648 681 TPR 3.
 DOMAIN 1036 1172 RanBD1 1.
 DOMAIN 1333 1469 RanBD1 2.
 DOMAIN 1702 1752 GRIP.
 MOD_RES 19 19 Phosphothreonine.
 MOD_RES 21 21 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1765 AA 
Protein Sequence
MRRSKADVER YVASVLGLTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP 60
KAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER 120
AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR 180
LKDAVAHCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA 240
NLMLLTLSTR DVQENRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMYAGSLLLK 300
MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLREGKAG QNLLEMMACD RLSQSGHMLL 360
SLSRGKQDFL KEVVETFANK IGQSALYDAL FSSQSPKDTS FLGSDDIGKI DVQEPELEDL 420
ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHRLPHETS RLETNAPESI 480
CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPFPV CKQLCTERQK SWWDAVCTLI 540
HRKAVPGNLA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KYLQKTGSGL NSFYGQLEYI 600
GRSVHYWKKV LPLLKIIKKN SIPEPIDPLF KHFHSVDIQA SEIVEYEEDA HITFAILDAV 660
NGNIEDAVTA FESIKSVVSY WNLALIFHRK AEDIENDALS PEEQEECRNY LTKTRDYLIK 720
IIDDGDSNLS VVKKLPVPLE SVKQMLNSVM QELEDYSEGG PLYKNGSLRN ADSEIKHSTP 780
SPTKYSLSPS KSYKYSPETP PRWTEDRNSL LNMICQQVEA IKKEMQELKL NSSKSASRHR 840
WPTENYGPDS VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLLR PAANVTPTKG 900
SSNTEFKSTK EGFSIPVSAD GFKFGISEPG NQEKKREKPL ENDTGLQAQD IRGRKKGRGV 960
IFGQTSSTFT FADVAKSTSG EGFQFGKKDL NFKGFSGAGE KLFSSRYGKM ANKANTSGDF 1020
EKDDDAYKTE DSDDIHFEPV VQMPEKVELV TGEEGEKVLY SQGVKLFRFD AEVRQWKERG 1080
LGNLKILKNE VNGKLRMLMR REQVLKVCAN HWITTTMNLK PLSGSDRAWM WSASDFSDGD 1140
AKLERLAAKF KTPELAEEFK QKFEECQRLL LDIPLQTPHK LVDTGRAAKL IQRAEEMKSG 1200
LKDFKTFLTN DQTKVTEEEN KGSGTGVAGA SDTTIKPNAE NTGPTLEWDN YDLREDALDD 1260
SVSSSSVHAS PLASSPVRKN LFRFDESTTG SNFSFKSALS LSKSPAKLNQ SGTSVGTDEE 1320
SVVTQEEERD GQYFEPVVPL PDLVEVSSGE ENEQVVFSHR AEIYRYDKDV GQWKERGIGD 1380
IKILQNYDNK QVRIVMRRDQ VLKLCANHRI TPDMSLQNMK GTERVWVWTA CDFADGERKV 1440
EHLAVRFKLQ DVADSFKKIF DEAKTAQEKD SLITPHVSRS STPRESPCGK IAVAVLEEIT 1500
RERTDVIQGD DVADAASEVE VSSTSETTTK AVVSPPKFVF VSESVKRIFS SEKSKPFAFG 1560
NSSATGSLFG FSFNAPLKSN NSETSSVAQS GSESKVEPKK CELSKNSDIE QSSDSKVKNL 1620
SASFPTEESS INYTFKTPEK EPPLWHAEFT KEELVQKLRS TTKSADHLNG LLREIEATNA 1680
VLMEQIKLLK SEIRRLERNQ EREKSAANLE YLKNVLLQFI FLKPGSERER LLPVINTMLQ 1740
LSPEEKGKLA AVAQDEEENP SRSSG 1765 
Gene Ontology
 GO:0005643; C:nuclear pore; NAS:UniProtKB.
 GO:0008536; F:Ran GTPase binding; NAS:UniProtKB.
 GO:0000042; P:protein targeting to Golgi; IEA:InterPro. 
Interpro
 IPR000237; GRIP.
 IPR011993; PH_like_dom.
 IPR000156; Ran_bind_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF01465; GRIP
 PF00638; Ran_BP1
 PF00515; TPR_1 
SMART
 SM00755; Grip
 SM00160; RanBD 
PROSITE
 PS50913; GRIP
 PS50196; RANBD1
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS