CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031189
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitogen-activated protein kinase kinase kinase 11 
Protein Synonyms/Alias
 cDNA FLJ53177, highly similar to Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25); cDNA, FLJ78931, highly similar to Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) 
Gene Name
 MAP3K11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MEHKTLKITDFGLAubiquitination[1]
242ISMPLDFKHRITVQAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 590 AA 
Protein Sequence
MEHKTLKITD FGLAREWHKT TQMSAAGTYA WMAPEVIKAS TFSKGSDVWS FGVLLWELLT 60
GEVPYRGIDC LAVAYGVAVN KLTLPIPSTC PEPFAQLMAD CWAQDPHRRP DFASILQQLE 120
ALEAQVLREM PRDSFHSMQE GWKREIQGLF DELRAKEKEL LSREEELTRA AREQRSQAEQ 180
LRRREHLLAQ WELEVFEREL TLLLQQVDRE RPHVRRRRGT FKRSKLRARD GGERISMPLD 240
FKHRITVQAS PGLDRRRNVF EVGPGDSPTF PRFRAIQLEP AEPGQAWGRQ SPRRLEDSSN 300
GERRACWAWG PSSPKPGEAQ NGRRRSRMDE ATWYLDSDDS SPLGSPSTPP ALNGNPPRPS 360
LEPEEPKRPV PAERGSSSGT PKLIQRALLR GTALLASLGL GRDLQPPGGP GRERGESPTT 420
PPTPTPAPCP TEPPPSPLIC FSLKTPDSPP TPAPLLLDLG IPVGQRSAKS PRREEEPRGG 480
TVSPPPGTSR SAPGTPGTPR SPPLGLISRP RPSPLRSRID PWSFVSAGPR PSPLPSPQPA 540
PRRAPWTLFP DSDPFWDSPP ANPFQGGPQD CRAQTKDMGA QAPWVPEAGP 590 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0004706; F:JUN kinase kinase kinase activity; IEA:Compara.
 GO:0008219; P:cell death; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR015785; MAPKKK9/10/11-like.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom. 
Pfam
 PF07714; Pkinase_Tyr 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM 
PRINTS
 PR00109; TYRKINASE.