UniProt Accession

 PIGH_HUMAN; Q14442; B2RAA4 

Genbank Protein ID

 L19783; BT006804; AK314108; CH471061; BC004100; BC071849 

Genbank Nucleotide ID

 AAA03545.1; AAP35450.1; BAG36801.1; EAW80942.1; AAH04100.1; AAH71849.1 

Protein Name

 Phosphatidylinositol N-acetylglucosaminyltransferase subunit H 

Protein Synonyms/Alias

 Phosphatidylinositol-glycan biosynthesis class H protein; PIG-H 

Gene Name

 PIGH 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
182	QEILAHQKATSTSP*	ubiquitination	[1, 2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Glycosyltransferase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 188 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0003824; F:catalytic activity; TAS:ProtInc.
 GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IEA:EC.
 GO:0006501; P:C-terminal protein lipidation; TAS:Reactome.
 GO:0016254; P:preassembly of GPI anchor in ER membrane; TAS:Reactome. 

Interpro

 IPR019328; GPI-GlcNAc_Trfase_PIG-H_dom. 

Pfam

 PF10181; PIG-H 

SMART

  

PROSITE

  

PRINTS