CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019782
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleosome assembly protein 1-like 4 
Protein Synonyms/Alias
 Nucleosome assembly protein 2; NAP-2 
Gene Name
 NAP1L4 
Gene Synonyms/Alias
 NAP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26KNASNTEKLTDQVMQubiquitination[1, 2]
71KRRINALKQLQVRCAubiquitination[1, 2, 3, 4]
94EVHDLERKYAALYQPubiquitination[1, 2, 3]
105LYQPLFDKRREFITGubiquitination[1, 4]
146SKVVVTEKAAATAEEubiquitination[2, 4]
192LKHLQDIKVKFSDPGubiquitination[2]
282GTVRTITKQVPNESFubiquitination[1, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 MOTIF 265 271 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 5 5 Phosphoserine.
 MOD_RES 7 7 Phosphoserine.
 MOD_RES 12 12 Phosphoserine.
 MOD_RES 51 51 Phosphothreonine.
 MOD_RES 54 54 Phosphoserine.
 MOD_RES 125 125 Phosphoserine.
 MOD_RES 304 304 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MADHSFSDGV PSDSVEAAKN ASNTEKLTDQ VMQNPRVLAA LQERLDNVPH TPSSYIETLP 60
KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ PLFDKRREFI TGDVEPTDAE 120
SEWHSENEEE EKLAGDMKSK VVVTEKAAAT AEEPDPKGIP EFWFTIFRNV DMLSELVQEY 180
DEPILKHLQD IKVKFSDPGQ PMSFVLEFHF EPNDYFTNSV LTKTYKMKSE PDKADPFSFE 240
GPEIVDCDGC TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFNPLKASG 300
DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE EGEEEELEGD 360
EEGEDEDDAE INPKV 375 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0051082; F:unfolded protein binding; TAS:ProtInc.
 GO:0006334; P:nucleosome assembly; TAS:ProtInc. 
Interpro
 IPR002164; NAP_family. 
Pfam
 PF00956; NAP 
SMART
  
PROSITE
  
PRINTS