UniProt Accession

 NHP6A_YEAST; P11632; D6W459 

Genbank Protein ID

 X15317; M95912; Z49219; Z71255; AY693230; BK006949 

Genbank Nucleotide ID

 CAA33377.1; AAA34754.1; CAA89171.1; CAA94998.1; AAT93249.1; DAA11475.1 

Protein Name

 Non-histone chromosomal protein 6A 

Protein Synonyms/Alias

  

Gene Name

 NHP6A 

Gene Synonyms/Alias

 NHPA; YPR052C; YP9499.09C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
60	KKLGEKWKALTPEEK	acetylation	[1]
85	KKRYESEKELYNATL	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6B. 

Sequence Annotation

 DNA_BIND 21 89 HMG box.  

Keyword

 3D-structure; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 93 AA 

Protein Sequence

Gene Ontology

 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0008301; F:DNA binding, bending; IDA:SGD.
 GO:0031491; F:nucleosome binding; IDA:SGD.
 GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
 GO:0006338; P:chromatin remodeling; IGI:SGD.
 GO:0034724; P:DNA replication-independent nucleosome organization; IDA:SGD.
 GO:0006298; P:mismatch repair; IC:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; IDA:SGD.
 GO:0070898; P:RNA polymerase III transcriptional preinitiation complex assembly; IDA:SGD. 

Interpro

 IPR009071; HMG_box_dom. 

Pfam

 PF00505; HMG_box 

SMART

 SM00398; HMG 

PROSITE

 PS50118; HMG_BOX_2 

PRINTS