UniProt Accession

 SL9A1_MOUSE; Q61165 

Genbank Protein ID

 U51112 

Genbank Nucleotide ID

 AAA92976.1 

Protein Name

 Sodium/hydrogen exchanger 1 

Protein Synonyms/Alias

 Na(+)/H(+) exchanger 1; NHE-1; Solute carrier family 9 member 1 

Gene Name

 Slc9a1 

Gene Synonyms/Alias

 Nhe1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
573	LIAGERSKEPQLIAF	ubiquitination	[1]
616	SMQNIHPKAVTSDRI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. 

Sequence Annotation

 REGION 520 543 Interaction with CHP2 (By similarity).
 MOD_RES 603 603 Phosphoserine.
 MOD_RES 606 606 Phosphoserine.
 MOD_RES 609 609 Phosphoserine.
 MOD_RES 697 697 Phosphoserine.
 MOD_RES 701 701 Phosphoserine (By similarity).
 MOD_RES 707 707 Phosphoserine.
 MOD_RES 727 727 Phosphoserine (By similarity).
 MOD_RES 730 730 Phosphoserine (By similarity).
 MOD_RES 733 733 Phosphoserine (By similarity).
 MOD_RES 755 755 Phosphothreonine.
 MOD_RES 790 790 Phosphoserine (By similarity).
 CARBOHYD 374 374 N-linked (GlcNAc...) (Potential).  

Keyword

 Antiport; Calmodulin-binding; Cell membrane; Complete proteome; Endoplasmic reticulum; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 820 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; TAS:MGI.
 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0015385; F:sodium:hydrogen antiporter activity; IDA:MGI.
 GO:0055007; P:cardiac muscle cell differentiation; IMP:MGI.
 GO:0016049; P:cell growth; IEA:Compara.
 GO:0071468; P:cellular response to acidity; ISS:UniProtKB.
 GO:0070997; P:neuron death; IEA:Compara.
 GO:0045760; P:positive regulation of action potential; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0010740; P:positive regulation of intracellular protein kinase cascade; IEA:Compara.
 GO:0035794; P:positive regulation of mitochondrial membrane permeability; IEA:Compara.
 GO:0051259; P:protein oligomerization; ISS:UniProtKB.
 GO:0051453; P:regulation of intracellular pH; IEA:Compara.
 GO:0006885; P:regulation of pH; IDA:MGI.
 GO:0051930; P:regulation of sensory perception of pain; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IEA:Compara.
 GO:0001101; P:response to acid; IMP:MGI.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0071436; P:sodium ion export; ISS:UniProtKB. 

Interpro

 IPR006153; Cation/H_exchanger.
 IPR018422; Cation/H_exchanger_CPA1.
 IPR001970; Na/H_exchanger_1.
 IPR004709; NaH_exchanger. 

Pfam

 PF00999; Na_H_Exchanger 

SMART

  

PROSITE

  

PRINTS

 PR01084; NAHEXCHNGR.
 PR01085; NAHEXCHNGR1.