CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037414
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DENN domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 DENND3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38SLEQVAYKKGVKHLSubiquitination[1]
39LEQVAYKKGVKHLSAubiquitination[1]
78ANCGTLGKTRMRSLRubiquitination[1]
90SLRKKREKPRPEQWKubiquitination[1]
421LLSSTDLKEGRAHRRubiquitination[1]
454VSIFRDVKNHLNYEHubiquitination[1]
471FNSEEFLKTRAPGDHubiquitination[1]
495YMFHSFLKARLNRRMubiquitination[1]
591AVLNVTPKSPYTFKIubiquitination[1, 2]
597PKSPYTFKIPEIHFPubiquitination[1, 2]
677IFPTDLVKRTVESMSubiquitination[1]
707LISEILDKPHEASKLubiquitination[1]
726KKFKLPKKHMQLGDFubiquitination[1]
735MQLGDFMKRVQESGIubiquitination[1]
744VQESGIVKDASIIHRubiquitination[1]
810CKLSSSVKTNLGVGKubiquitination[1, 2]
817KTNLGVGKIAMTQKRubiquitination[1]
896KEMWAGKKLADDHKDubiquitination[1]
941SKLSYFDKMSNEMPMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1278 AA 
Protein Sequence
MAEAASPHLS LPSGLLELCA LLGAPRDSLR SLEQVAYKKG VKHLSALLDP EVLSIFVPPF 60
ISKEDSQMAG ANCGTLGKTR MRSLRKKREK PRPEQWKGLP GPPRAPEPED VAVPGGVDLL 120
TLPQLCFPGG VCVATEPKED CVHFLVLTDV CGNRTYGVVA QYYRPLHDEY CFYNGKTHRE 180
CPGCFVPFAV CVVSRFPYYN SLKDCLSCLL ALLKPCKDFE VDSHIKDFAA KLSLIPSPPP 240
GPLHLVFNMK SLQIVLPARA DPESPILDLD LHLPLLCFRP EKVLQILTCI LTEQRIVFFS 300
SDWALLTLVT ECFMAYLYPL QWQHPFVPIL SDQMLDFVMA PTSFLMGCHL DHFEEVSKEA 360
DGLVLINIDH GSITYSKSTD DNVDIPDVPL LAAQTFIQRV QSLQLHHELH AAHLLSSTDL 420
KEGRAHRRSW QQKLNCQIQQ TTLQLLVSIF RDVKNHLNYE HRVFNSEEFL KTRAPGDHQF 480
YKQVLDTYMF HSFLKARLNR RMDAFAQMDL DTQSEEDRIN GMLLSPRRPT VEKRASRKSS 540
HLHVTHRRMV VSMPNLQDIA MPELAPRNSS LRLTDTAGCR GSSAVLNVTP KSPYTFKIPE 600
IHFPLESKCV QAYHAHFVSM LSEAMCFLAP DNSLLLARYL YLRGLVYLMQ GQLLNALLDF 660
QNLYKTDIRI FPTDLVKRTV ESMSAPEWEG AEQAPELMRL ISEILDKPHE ASKLDDHVKK 720
FKLPKKHMQL GDFMKRVQES GIVKDASIIH RLFEALTVGQ EKQIDPETFK DFYNCWKETE 780
AEAQEVSLPW LVMEHLDKNE CVCKLSSSVK TNLGVGKIAM TQKRLFLLTE GRPGYLEIST 840
FRNIEEVRRT TTTFLLRRIP TLKIRVASKK EVFEANLKTE CDLWHLMVKE MWAGKKLADD 900
HKDPHYVQQA LTNVLLMDAV VGTLQSPGAI YAASKLSYFD KMSNEMPMTL PETTLETLKH 960
KINPSAGEAF PQAVDVLLYT PGHLDPAEKV EDAHPKLWCA LSEGKVTVFN ASSWTIHQHS 1020
FKVGTAKVNC MVMADQNQVW VGSEDSVIYI INVHSMSCNK QLTAHCSSVT DLIVQDGQEA 1080
PSNVYSCSMD GMVLVWNVST LQVTSRFQLP RGGLTSIRLH GGRLWCCTGN SIMVMKMNGS 1140
LHQELKIEEN FKDTSTSFLA FQLLPEEEQL WAACAGRSEV YIWSLKDLAQ PPQRVPLEDC 1200
SEINCMIRVK KQVWVGSRGL GQGTPKGKIY VIDAERKTVE KELVAHMDTV RTLCSAEDRY 1260
VLSGSGREEG KVAIWKGE 1278 
Gene Ontology
  
Interpro
 IPR005112; dDENN_dom.
 IPR001194; DENN_dom.
 IPR005113; uDENN_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF03455; dDENN
 PF02141; DENN
 PF03456; uDENN
 PF00400; WD40 
SMART
 SM00801; dDENN
 SM00799; DENN
 SM00800; uDENN
 SM00320; WD40 
PROSITE
 PS50947; DDENN
 PS50211; DENN
 PS50946; UDENN
 PS00678; WD_REPEATS_1
 PS50294; WD_REPEATS_REGION 
PRINTS