UniProt Accession

 RB39A_MOUSE; Q8BHD0 

Genbank Protein ID

 AK049038; AK053487; BC049787 

Genbank Nucleotide ID

 BAC33522.1; BAC35399.1; AAH49787.1 

Protein Name

 Ras-related protein Rab-39A 

Protein Synonyms/Alias

 Rab-39 

Gene Name

 Rab39a 

Gene Synonyms/Alias

 Rab39 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
63	IEPGKRIKLQLWDTA	acetylation	[1]
63	IEPGKRIKLQLWDTA	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes (By similarity). 

Sequence Annotation

 NP_BIND 15 22 GTP (By similarity).
 NP_BIND 68 72 GTP (By similarity).
 NP_BIND 127 130 GTP (By similarity).
 MOTIF 41 49 Effector region (By similarity).
 MOD_RES 217 217 Cysteine methyl ester (By similarity).
 LIPID 215 215 S-geranylgeranyl cysteine (By
 LIPID 217 217 S-geranylgeranyl cysteine (By  

Keyword

 Cell membrane; Complete proteome; Cytoplasmic vesicle; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0090383; P:phagosome acidification; ISS:UniProtKB.
 GO:0090385; P:phagosome-lysosome fusion; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.