UniProt Accession

 ADRM1_MOUSE; Q9JKV1; Q3UKZ8; Q8BPH8; Q922A7 

Genbank Protein ID

 AF225959; AK075674; AK145474; AK145792; AK166878; AL663027; BC008974; BC031517 

Genbank Nucleotide ID

 AAF33401.1; BAC35889.1; BAE26457.1; BAE26653.1; BAE39089.1; CAM16214.1; AAH08974.1; AAH31517.1 

Protein Name

 Proteasomal ubiquitin receptor ADRM1 

Protein Synonyms/Alias

 110 kDa cell membrane glycoprotein; Gp110; Adhesion-regulating molecule 1; ARM-1; Rpn13 homolog 

Gene Name

 Adrm1 

Gene Synonyms/Alias

 Gp110 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	GSRGSSTKYLVEFRA	ubiquitination	[1]
34	RAGKMSLKGTTVTPD	ubiquitination	[1]
379	GDVEAFAKAMQNNAK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity. 

Sequence Annotation

 DOMAIN 22 130 PH.
 REGION 2 132 Interaction with PSMD1.
 REGION 362 407 Interaction with UCHL5 (By similarity).
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 211 211 Phosphoserine (By similarity).
 MOD_RES 213 213 Phosphoserine.
 MOD_RES 217 217 Phosphothreonine (By similarity).
 CROSSLNK 34 34 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Isopeptide bond; Nucleus; Phosphoprotein; Proteasome; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 407 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
 GO:0060612; P:adipose tissue development; IMP:BHF-UCL.
 GO:0042699; P:follicle-stimulating hormone signaling pathway; IMP:BHF-UCL.
 GO:0048477; P:oogenesis; IMP:BHF-UCL.
 GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; IMP:BHF-UCL.
 GO:0033081; P:regulation of T cell differentiation in thymus; IMP:BHF-UCL.
 GO:0072520; P:seminiferous tubule development; IMP:BHF-UCL.
 GO:0060009; P:Sertoli cell development; IMP:BHF-UCL.
 GO:0007286; P:spermatid development; IMP:BHF-UCL.
 GO:0048538; P:thymus development; IMP:BHF-UCL. 

Interpro

 IPR006773; 26S_Psome_Ubiquitin-recp_Rpn13. 

Pfam

 PF04683; Proteasom_Rpn13 

SMART

  

PROSITE

 PS50003; PH_DOMAIN 

PRINTS