| Tag | Content |
|---|
| CPLM ID | CPLM-013996 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kinesin-like protein KIF24 |
Protein Synonyms/Alias | |
Gene Name | KIF24 |
Gene Synonyms/Alias | C9orf48 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 42 | ITMKDYSKLGVHDMN | ubiquitination | [1] | | 59 | KRLFQLIKIIKIMQE | ubiquitination | [1] | | 69 | KIMQEEDKAVSIPER | ubiquitination | [1] | | 107 | FDSPADNKDRNASND | ubiquitination | [1] | | 130 | DFSANEQKSTYLKVL | ubiquitination | [1] | | 135 | EQKSTYLKVLEHMLP | ubiquitination | [1] | | 214 | IRQNTSEKQNPWTEM | ubiquitination | [1] | | 223 | NPWTEMEKIRVCVRK | ubiquitination | [1] | | 469 | RDSDRQTKMEGAEIN | ubiquitination | [1] | | 483 | NQSLLALKECIRALD | ubiquitination | [1] | | 502 | HTPFRQSKLTQVLKD | ubiquitination | [1] | | 508 | SKLTQVLKDSFIGNA | ubiquitination | [1] | | 516 | DSFIGNAKTCMIANI | ubiquitination | [1] | | 551 | KELKKGIKCCTSVTS | ubiquitination | [1] | | 714 | QTVQPVQKQLVSRVE | ubiquitination | [1] | | 780 | QPPLLQQKLKYQPLK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress abberrant cilia formation. |
Sequence Annotation | DOMAIN 1 64 SAM.
DOMAIN 220 477 Kinesin-motor.
NP_BIND 313 320 ATP (Potential).
MOD_RES 102 102 Phosphoserine.
MOD_RES 112 112 Phosphoserine.
MOD_RES 478 478 Phosphoserine.
MOD_RES 646 646 Phosphoserine.
MOD_RES 1012 1012 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1368 AA |
Protein Sequence | MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND RKRLFQLIKI 60
IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF DSPADNKDRN ASNDGFEMCS 120
LSDFSANEQK STYLKVLEHM LPDDSQYHTK TGILNATAGD SYVQTEISTS LFSPNYLSAI 180
LGDCDIPIIQ RISHVSGYNY GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR 240
GEINIITVED KETLLVHEKK EAVDLTQYIL QHVFYFDEVF GEACTNQDVY MKTTHPLIQH 300
IFNGGNATCF AYGQTGAGKT YTMIGTHENP GLYALAAKDI FRQLEVSQPR KHLFVWISFY 360
EIYCGQLYDL LNRRKRLFAR EDSKHMVQIV GLQELQVDSV ELLLEVILKG SKERSTGATG 420
VNADSSRSHA VIQIQIKDSA KRTFGRISFI DLAGSERAAD ARDSDRQTKM EGAEINQSLL 480
ALKECIRALD QEHTHTPFRQ SKLTQVLKDS FIGNAKTCMI ANISPSHVAT EHTLNTLRYA 540
DRVKELKKGI KCCTSVTSRN RTSGNSSPKR IQSSPGALSE DKCSPKKVKL GFQQSLTVAA 600
PGSTRGKVHP LTSHPPNIPF TSAPKVSGKR GGSRGSPSQE WVIHASPVKG TVRSGHVAKK 660
KPEESAPLCS EKNRMGNKTV LGWESRASGP GEGLVRGKLS TKCKKVQTVQ PVQKQLVSRV 720
ELSFGNAHHR AEYSQDSQRG TPARPASEAW TNIPPHQKER EEHLRFYHQQ FQQPPLLQQK 780
LKYQPLKRSL RQYRPPEGQL TNETPPLFHS YSENHDGAQV EELDDSDFSE DSFSHISSQR 840
ATKQRNTLEN SEDSFFLHQT WGQGPEKQVA ERQQSLFSSP RTGDKKDLTK SWVDSRDPIN 900
HRRAALDHSC SPSKGPVDWS RENSTSSGPS PRDSLAEKPY CSQVDFIYRQ ERGGGSSFDL 960
RKDASQSEVS GENEGNLPSP EEDGFTISLS HVAVPGSPDQ RDTVTTPLRE VSADGPIQVT 1020
STVKNGHAVP GEDPRGQLGT HAEYASGLMS PLTMSLLENP DNEGSPPSEQ LVQDGATHSL 1080
VAESTGGPVV SHTVPSGDQE AALPVSSATR HLWLSSSPPD NKPGGDLPAL SPSPIRQHPA 1140
DKLPSREADL GEACQSRETV LFSHEHMGSE QYDADAEETG LDGSWGFPGK PFTTIHMGVP 1200
HSGPTLTPRT GSSDVADQLW AQERKHPTRL GWQEFGLSTD PIKLPCNSEN VTWLKPRPIS 1260
RCLARPSSPL VPSCSPKTAG TLRQPTLEQA QQVVIRAHQE QLDEMAELGF KEETLMSQLA 1320
SNDFEDFVTQ LDEIMVLKSK CIQSLRSQLQ LYLTCHGPTA APEGTVPS 1368 |
Gene Ontology | GO:0005814; C:centriole; IDA:UniProtKB. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005875; C:microtubule associated complex; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003777; F:microtubule motor activity; IDA:UniProtKB. GO:0042384; P:cilium assembly; IMP:UniProtKB. GO:0007019; P:microtubule depolymerization; IDA:UniProtKB. GO:0007018; P:microtubule-based movement; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |