UniProt Accession

 STE2_YEAST; D6VTK4; P06842; Q70D63; Q70D65; Q70D69; Q70D73; Q70D74 

Genbank Protein ID

 X03010; M24335; AJ585736; D50617; AY693134; BK006940 

Genbank Nucleotide ID

 CAA26794.1; AAA35112.1; CAE52256.1; BAA09212.1; AAT93153.1; DAA12414.2 

Protein Name

 Pheromone alpha factor receptor 

Protein Synonyms/Alias

  

Gene Name

 STE2 

Gene Synonyms/Alias

 YFL026W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
337	DSINNDAKSSLRSRL	ubiquitination	[1, 2]
374	ETADDIEKNQFYQLP	ubiquitination	[1, 2, 3]
387	LPTPTSSKNTRIGPF	ubiquitination	[2]
400	PFADASYKEGEVEPV	ubiquitination	[2, 3]
422	AADEEARKFWTEDNN	ubiquitination	[2, 3]

Reference

 [1] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Receptor for the peptide pheromone alpha factor, the mating factor of yeast. 

Sequence Annotation

 MOD_RES 310 310 Phosphoserine.
 MOD_RES 315 315 Phosphoserine.
 MOD_RES 329 329 Phosphothreonine.
 MOD_RES 331 331 Phosphoserine.
 MOD_RES 360 360 Phosphoserine.
 MOD_RES 363 363 Phosphothreonine.
 MOD_RES 366 366 Phosphoserine.
 MOD_RES 382 382 Phosphothreonine.
 MOD_RES 385 385 Phosphoserine.
 MOD_RES 386 386 Phosphoserine.
 MOD_RES 411 411 Phosphothreonine.
 MOD_RES 414 414 Phosphothreonine.
 CARBOHYD 25 25 N-linked (GlcNAc...).
 CARBOHYD 32 32 N-linked (GlcNAc...).  

Keyword

 3D-structure; Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; Pheromone response; Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 431 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; IDA:SGD.
 GO:0004934; F:mating-type alpha-factor pheromone receptor activity; IDA:SGD.
 GO:0030031; P:cell projection assembly; IMP:SGD.
 GO:0000755; P:cytogamy; IDA:SGD.
 GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD.
 GO:0051260; P:protein homooligomerization; IPI:SGD. 

Interpro

 IPR000366; GPCR_STE2.
 IPR027458; STE2_TM1-TM2. 

Pfam

 PF02116; STE2 

SMART

  

PROSITE

  

PRINTS

 PR00250; GPCRSTE2.