UniProt Accession

 ACTG_HUMAN; P63261; A8K7C2; P02571; P14104; P99022; Q5U032; Q96E67 

Genbank Protein ID

 X04098; M19283; AK291937; BT019856; BC000292; BC001920; BC007442; BC009848; BC010999; BC012050; BC015005; BC015695; BC015779; BC018774; BC053572; M16247 

Genbank Nucleotide ID

 CAA27723.1; AAA51579.1; BAF84626.1; AAV38659.1; AAH00292.1; AAH01920.1; AAH07442.1; AAH09848.1; AAH10999.1; AAH12050.1; AAH15005.1; AAH15695.1; AAH15779.1; AAH18774.1; AAH53572.1; AAA51580.1 

Protein Name

 Actin, cytoplasmic 2 

Protein Synonyms/Alias

 Gamma-actin; Actin, cytoplasmic 2, N-terminally processed 

Gene Name

 ACTG1 

Gene Synonyms/Alias

 ACTB; ACTG 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	DNGSGMCKAGFAGDD	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylglutamate; in Actin, cytoplasmic
 MOD_RES 44 44 Methionine sulfoxide (By similarity).
 MOD_RES 73 73 Tele-methylhistidine.
 MOD_RES 169 169 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Deafness; Direct protein sequencing; Disease mutation; Mental retardation; Methylation; Non-syndromic deafness; Nucleotide-binding; Oxidation; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; TAS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0031941; C:filamentous actin; IEA:Compara.
 GO:0030016; C:myofibril; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005200; F:structural constituent of cytoskeleton; IC:UniProtKB.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0006928; P:cellular component movement; TAS:UniProtKB.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0045214; P:sarcomere organization; IEA:Compara. 

Interpro

 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 

PRINTS

 PR00190; ACTIN.