Tag | Content |
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CPLM ID | CPLM-018443 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | C-type lectin domain family 2 member D |
Protein Synonyms/Alias | C-type lectin-related protein B; Clr-b; Lectin-like transmembrane protein; Osteoclast inhibitory lectin |
Gene Name | Clec2d |
Gene Synonyms/Alias | Clrb; Ocil |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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24 | PQEVEVGKILQGKRH | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Binds high molecular weight sulfated glycosaminoglycans. |
Sequence Annotation | DOMAIN 87 202 C-type lectin. CARBOHYD 100 100 N-linked (GlcNAc...) (Potential). DISULFID 80 91 By similarity. |
Keyword | Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 207 AA |
Protein Sequence | MCVTKASLPM LSPTGSPQEV EVGKILQGKR HGTISPESCA KLYCYYGVIM VLTVAVIALS 60 VALSATKTEQ IPVNKTYAAC PQNWIGVENK CFYFSEYPSN WTFAQAFCMA QEAQLARFDN 120 QDELNFLMRY KANFDSWIGL HRESSEHPWK WTDNTEYNNT IPIRGEERFA YLNNNGISST 180 RIYSLRMWIC SKLNSYSLHC QTPFFPS 207 |
Gene Ontology | GO:0009897; C:external side of plasma membrane; IDA:MGI. GO:0005887; C:integral to plasma membrane; TAS:MGI. GO:0030246; F:carbohydrate binding; ISS:MGI. GO:0046703; F:natural killer cell lectin-like receptor binding; IDA:MGI. GO:0004888; F:transmembrane signaling receptor activity; ISS:MGI. GO:0006968; P:cellular defense response; TAS:MGI. GO:0045671; P:negative regulation of osteoclast differentiation; IDA:MGI. GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:MGI. |
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PRINTS | |