UniProt Accession

 FKB10_MOUSE; Q61576; A2A4I0; Q8VHI1 

Genbank Protein ID

 L07063; AF456413; AF456412; AL590968; CH466662; BC029546 

Genbank Nucleotide ID

 AAC37678.1; AAL57621.1; AAL57621.1; CAM23033.1; EDL02562.1; AAH29546.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase FKBP10 

Protein Synonyms/Alias

 PPIase FKBP10; 65 kDa FK506-binding protein; 65 kDa FKBP; FKBP-65; FK506-binding protein 10; FKBP-10; Immunophilin FKBP65; Rotamase 

Gene Name

 Fkbp10 

Gene Synonyms/Alias

 Fkbp-rs; Fkbp1-rs; Fkbp6; Fkbp65; Fkbprp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
225	LGMCPGEKRKIIIPP	acetylation	[1, 2]
225	LGMCPGEKRKIIIPP	succinylation	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 PPIases accelerate the folding of proteins during protein synthesis. 

Sequence Annotation

 DOMAIN 61 149 PPIase FKBP-type 1.
 DOMAIN 173 261 PPIase FKBP-type 2.
 DOMAIN 285 373 PPIase FKBP-type 3.
 DOMAIN 398 485 PPIase FKBP-type 4.
 DOMAIN 496 531 EF-hand 1.
 DOMAIN 541 576 EF-hand 2.
 MOTIF 578 581 Prevents secretion from ER (Potential).
 CARBOHYD 69 69 N-linked (GlcNAc...) (Potential).
 CARBOHYD 181 181 N-linked (GlcNAc...) (Potential).
 CARBOHYD 293 293 N-linked (GlcNAc...) (Potential).
 CARBOHYD 309 309 N-linked (GlcNAc...) (Potential).
 CARBOHYD 351 351 N-linked (GlcNAc...) (Potential).
 CARBOHYD 392 392 N-linked (GlcNAc...) (Potential).
 CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).  

Keyword

 Calcium; Complete proteome; Endoplasmic reticulum; Glycoprotein; Isomerase; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Rotamase; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 581 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 

Pfam

 PF13202; EF_hand_3
 PF00254; FKBP_C 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00014; ER_TARGET
 PS50059; FKBP_PPIASE 

PRINTS