UniProt Accession

 RBBP4_HUMAN; Q09028; B2R6G9; B4DRH0; D3DPQ3; P31149; Q53H02; Q96BV9 

Genbank Protein ID

 X74262; X71810; BT007309; AK299251; AK312571; AK222779; AC114489; CH471059; CH471059; BC003092; BC015123; BC053904; BC075836 

Genbank Nucleotide ID

 CAA52321.1; CAA50685.1; AAP35973.1; BAG61282.1; BAG35466.1; BAD96499.1; EAX07513.1; EAX07514.1; AAH03092.1; AAH15123.1; AAH53904.1; AAH75836.1 

Protein Name

 Histone-binding protein RBBP4 

Protein Synonyms/Alias

 Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48 

Gene Name

 RBBP4 

Gene Synonyms/Alias

 RBAP48 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MADKEAFDDAV	ubiquitination	[1]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. 

Sequence Annotation

 REPEAT 122 155 WD 1.
 REPEAT 175 206 WD 2.
 REPEAT 225 256 WD 3.
 REPEAT 271 302 WD 4.
 REPEAT 315 346 WD 5.
 REPEAT 372 403 WD 6.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 4 4 N6-acetyllysine; alternate.
 MOD_RES 110 110 Phosphoserine.
 CROSSLNK 4 4 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cell cycle; Chromatin regulator; Complete proteome; Direct protein sequencing; DNA replication; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 425 AA 

Protein Sequence

Gene Ontology

 GO:0033186; C:CAF-1 complex; IDA:UniProtKB.
 GO:0035098; C:ESC/E(Z) complex; IDA:UniProtKB.
 GO:0016581; C:NuRD complex; IDA:UniProtKB.
 GO:0016589; C:NURF complex; IDA:UniProtKB.
 GO:0016580; C:Sin3 complex; NAS:BHF-UCL.
 GO:0042393; F:histone binding; NAS:BHF-UCL.
 GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:Reactome.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR022052; Histone-bd_RBBP4.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF12265; CAF1C_H4-bd
 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.