UniProt Accession

 LRAT_MOUSE; Q9JI60 

Genbank Protein ID

 AF255061; AK004953 

Genbank Nucleotide ID

 AAF97787.1; BAB23696.1 

Protein Name

 Lecithin retinol acyltransferase 

Protein Synonyms/Alias

 Phosphatidylcholine--retinol O-acyltransferase; Phosphatidylcholine-retinol-O-acyltransferase 

Gene Name

 Lrat 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
134	LDGTLKKKSLLNEEV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (By similarity). 

Sequence Annotation

 ACT_SITE 161 161 Acyl-thioester intermediate.  

Keyword

 Acyltransferase; Complete proteome; Cytoplasm; Endoplasmic reticulum; Endosome; Membrane; Reference proteome; Sensory transduction; Transferase; Transmembrane; Transmembrane helix; Vision. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005771; C:multivesicular body; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0008374; F:O-acyltransferase activity; IDA:MGI.
 GO:0047173; F:phosphatidylcholine-retinol O-acyltransferase activity; IEA:EC.
 GO:0001972; F:retinoic acid binding; IEA:Compara.
 GO:0019841; F:retinol binding; IEA:Compara.
 GO:0006653; P:1,2-diacyl-sn-glycero-3-phosphocholine metabolic process; TAS:MGI.
 GO:0009790; P:embryo development; IGI:MGI.
 GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
 GO:0042573; P:retinoic acid metabolic process; IEA:Compara.
 GO:0042572; P:retinol metabolic process; IMP:MGI.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW.
 GO:0006776; P:vitamin A metabolic process; IDA:MGI. 

Interpro

 IPR007053; LRAT-like_dom. 

Pfam

 PF04970; LRAT 

SMART

  

PROSITE

  

PRINTS