CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044438
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 GRAM domain-containing protein 1A 
Protein Synonyms/Alias
  
Gene Name
 GRAMD1A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
182SPWSGDSKCHQRRVLubiquitination[1]
202ISNPLGPKSASVVETubiquitination[1]
267SSEIRYRKQPWSLVKubiquitination[1]
279LVKSLIEKNSWSGIEubiquitination[1]
301RELAKAEKLSLEEGGmethylation[2]
301RELAKAEKLSLEEGGubiquitination[1]
309LSLEEGGKDARGLLSmethylation[2]
309LSLEEGGKDARGLLSubiquitination[1]
417SLALAKGKFPQTATEubiquitination[3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 486 AA 
Protein Sequence
MHCLKRTPKE VGDVIALSDI TSSGAADRSQ EPSPVGSRRG HVTPNLSRAS SDADHGAEED 60
KEEQVDSQPD ASSSQTVTPV AEPPSTEPTQ PDGPTTLGPL DLLPSEELLT DTSNSSSSTG 120
EEADLAALLP DLSGRLLINS VFHVGAERLQ QMLFSDSPFL QGFLQQCKFT DVTLSPWSGD 180
SKCHQRRVLT YTIPISNPLG PKSASVVETQ TLFRRGPQAG GCVVDSEVLT QGIPYQDYFY 240
TAHRYCILGL ARNKARLRVS SEIRYRKQPW SLVKSLIEKN SWSGIEDYFH HLERELAKAE 300
KLSLEEGGKD ARGLLSGLRR RKRPLSWRAH GDGPQHPDPD PCARAGIHTS GSLSSRFSEP 360
SVDQGPGAGI PSALVLISIV LIILIALNVL LFYRLWSLER TAHTFESWHS LALAKGKFPQ 420
TATEWAEILA LQKQFHSVEV HKWRQILRAS VELLDEMKFS LEKLHQGITV SDPPFDTQPR 480
PDDSFS 486 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS