UniProt Accession

 HS905_HUMAN; Q58FG0 

Genbank Protein ID

 AY956761 

Genbank Nucleotide ID

 AAX38248.1 

Protein Name

 Putative heat shock protein HSP 90-alpha A5 

Protein Synonyms/Alias

 Heat shock protein 90-alpha E; Heat shock protein 90Ae 

Gene Name

 HSP90AA5P 

Gene Synonyms/Alias

 HSP90AE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
39	RIKEIVKKHSQFIGY	ubiquitination	[1]
118	DQELNKTKPIWTRNP	ubiquitination	[1]
250	KKKQEEKKTKFENLC	ubiquitination	[1]
252	KQEEKKTKFENLCKI	ubiquitination	[1]
266	IMKDMLEKKVKKVVV	acetylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins (By similarity). 

Sequence Annotation

 MOTIF 327 331 TPR repeat-binding.  

Keyword

 ATP-binding; Chaperone; Coiled coil; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR003594; HATPase_ATP-bd.
 IPR001404; Hsp90.
 IPR020568; Ribosomal_S5_D2-typ_fold. 

Pfam

 PF00183; HSP90 

SMART

  

PROSITE

  

PRINTS