UniProt Accession

 FLT3L_HUMAN; P49771; A0AVC2; B9EGH2 

Genbank Protein ID

 U04806; U03858; U29874; U29874; BC126293; BC136464 

Genbank Nucleotide ID

 AAA17999.1; AAA19825.1; AAA90949.1; AAA90950.1; AAI26294.1; AAI36465.1 

Protein Name

 Fms-related tyrosine kinase 3 ligand 

Protein Synonyms/Alias

 Flt3 ligand; Flt3L; SL cytokine 

Gene Name

 FLT3LG 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
142	SEQLVALKPWITRQN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 

Sequence Annotation

 CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
 CARBOHYD 149 149 N-linked (GlcNAc...) (Potential).
 DISULFID 30 111
 DISULFID 70 153
 DISULFID 119 158  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 235 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005102; F:receptor binding; TAS:ProtInc.
 GO:0035162; P:embryonic hemopoiesis; IDA:DFLAT.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR009079; 4_helix_cytokine-like_core.
 IPR012351; 4_helix_cytokine_core.
 IPR004213; Flt3_lig. 

Pfam

 PF02947; Flt3_lig 

SMART

  

PROSITE

  

PRINTS