CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031949
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor-type tyrosine-protein phosphatase alpha 
Protein Synonyms/Alias
 cDNA FLJ56484, highly similar to Receptor-type tyrosine-protein phosphatase alpha (EC 3.1.3.48) 
Gene Name
 PTPRA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
572NLPANMKKNRVLQIIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protein phosphatase; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 813 AA 
Protein Sequence
MDDAVQITKI SMDSWFILVL LGSGLICVSA NNATTVAPSV GITRLINSST AEPVKEEAKT 60
SNPTSSLTSL SVAPTFSPNI TLGPTYLTTV NSSDSDNGTT RTASTNSIGI TISPNGTWLP 120
DNQFTDARTE PWEGNSSTAA TTPETFPPSG NSDSKDRRDE TPIIAVMVAL SSLLVIVFII 180
IVLYMLRFKK YKQAGSHSNS FRLSNGRTED VEPQSVPLLA RSPSTNRKYP PLPVDKLEEE 240
INRRMADDNK LFREEFNALP ACPIQATCEA ASKEENKEKN RYVNILPYDH SRVHLTPVEG 300
VPDSDYINAS FINGYQEKNK FIAAQGPKEE TVNDFWRMIW EQNTATIVMV TNLKERKECK 360
CAQYWPDQGC WTYGNIRVSV EDVTVLVDYT VRKFCIQQVG DMTNRKPQRL ITQFHFTSWP 420
DFGVPFTPIG MLKFLKKVKA CNPQYAGAIV VHCSAGVGRT GTFVVIDAML DMMHTERKVD 480
VYGFVSRIRA QRCQMVQTDM QYVFIYQALL EHYLYGDTEL EVTSLETHLQ KIYNKIPGTS 540
NNGLEEEFKK LTSIKIQNDK MRTGNLPANM KKNRVLQIIP YEFNRVIIPV KRGEENTDYV 600
NASFIDGYRQ KDSYIASQGP LLHTIEDFWR MIWEWKSCSI VMLTELEERG QEKCAQYWPS 660
DGLVSYGDIT VELKKEEECE SYTVRDLLVT NTRENKSRQI RQFHFHGWPE VGIPSDGKGM 720
ISIIAAVQKQ QQQSGNHPIT VHCSAGAGRT GTFCALSTVL ERVKAEGILD VFQTVKSLRL 780
QRPHMVQTLE QYEFCYKVVQ EYIDAFSDYA NFK 813 
Gene Ontology
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt.
 IPR016336; Tyr_Pase_rcpt_a/e-type.
 IPR027262; Tyr_Pase_rcpt_alpha. 
Pfam
 PF00102; Y_phosphatase 
SMART
 SM00194; PTPc 
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00700; PRTYPHPHTASE.