UniProt Accession

 H4_PHYPO; P04915 

Genbank Protein ID

 X00449; X15141; X15142; Y00366 

Genbank Nucleotide ID

 CAA25140.1; CAA33239.1; CAA33240.1; CAA68442.1 

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

 H41; H42 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Physarum polycephalum (Slime mold) 

NCBI Taxa ID

 5791 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKGGKGLGK	acetylation	[1]
9	SGRGKGGKGLGKGGA	acetylation	[2, 3]
13	KGGKGLGKGGAKRHR	acetylation	[2, 3]
17	GLGKGGAKRHRKVLR	acetylation	[2, 3]

Reference

 [1] Acetylation and methylation sites in histone H4 from Physarum polycephalum.
 Waterborg JH, Fried SR, Matthews HR.
 Eur J Biochem. 1983 Nov 2;136(2):245-52. [PMID: 6628379]
 [2] Histone acetylation in replication and transcription: turnover at specific acetylation sites in histone H4 from Physarum polycephalum.
 Pesis KH, Matthews HR.
 Arch Biochem Biophys. 1986 Dec;251(2):665-73. [PMID: 3800393]
 [3] Tetrahymena histone H2B. Complete amino acid sequence.
 Nomoto M, Hayashi H, Iwai K.
 J Biochem. 1982 Mar;91(3):897-904. [PMID: 6804458] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 DNA_BIND 17 21  

Keyword

 Chromosome; DNA-binding; Nucleosome core; Nucleus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.