UniProt Accession

 AGFG2_HUMAN; O95081; O75429; Q96AB9; Q96GL4 

Genbank Protein ID

 AF015042; BC009393; BC017329; AF053356 

Genbank Nucleotide ID

 AAD01550.1; AAH09393.1; AAH17329.1; AAC78803.1 

Protein Name

 Arf-GAP domain and FG repeat-containing protein 2 

Protein Synonyms/Alias

 HIV-1 Rev-binding protein-like protein; Rev/Rex activation domain-binding protein related; RAB-R 

Gene Name

 AGFG2 

Gene Synonyms/Alias

 HRBL; RABR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
173	QGSIPEGKPLRTLLG	acetylation	[1, 2, 3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

 DOMAIN 27 153 Arf-GAP.
 ZN_FING 47 70 C4-type.
 MOD_RES 173 173 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Metal-binding; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 481 AA 

Protein Sequence

Gene Ontology

 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. 

Interpro

 IPR001164; ArfGAP. 

Pfam

 PF01412; ArfGap 

SMART

 SM00105; ArfGap 

PROSITE

 PS50115; ARFGAP 

PRINTS

 PR00405; REVINTRACTNG.