UniProt Accession

 PNKD_MOUSE; Q69ZP3; Q3TLE6; Q6PD45; Q8BRV8; Q920D4; Q9CSF5; Q9D765; Q9JJA3 

Genbank Protein ID

 AY039041; AY039042; AB041609; AF318058; AY299972; AK173125; AK009545; AK012976; AK041238; AK166548; BC008274; BC058945; BC116236; BC116237 

Genbank Nucleotide ID

 AAK83447.1; AAK83448.1; BAA95092.1; AAL25717.1; AAP58373.1; BAD32403.1; BAB26351.1; BAB28577.2; BAC30873.1; BAE38846.1; AAH08274.1; AAH58945.1; AAI16237.1; AAI16238.1 

Protein Name

 Probable hydrolase PNKD 

Protein Synonyms/Alias

 Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein 

Gene Name

 Pnkd 

Gene Synonyms/Alias

 Brp17; Kiaa1184; Mr1; Tahccp2; Fksg19; MNCb-5687 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
199	AVQASIEKERVNLVA	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway. 

Sequence Annotation

 REGION 291 293 Substrate (By similarity).
 REGION 376 379 Substrate (By similarity).
 METAL 172 172 Zinc 1 (By similarity).
 METAL 174 174 Zinc 1 (By similarity).
 METAL 176 176 Zinc 2 (By similarity).
 METAL 177 177 Zinc 2 (By similarity).
 METAL 229 229 Zinc 1 (By similarity).
 METAL 253 253 Zinc 1 (By similarity).
 METAL 253 253 Zinc 2 (By similarity).
 METAL 291 291 Zinc 2 (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Membrane; Metal-binding; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 385 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004416; F:hydroxyacylglutathione hydrolase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006750; P:glutathione biosynthetic process; IEA:InterPro. 

Interpro

 IPR001279; Beta-lactamas-like.
 IPR017782; Hydroxyacylglutathione_Hdrlase. 

Pfam

 PF00753; Lactamase_B 

SMART

 SM00849; Lactamase_B 

PROSITE

  

PRINTS