CPLM-013985

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-013985

UniProt Accession

CAMP1_HUMAN; Q5T5Y3; A1L4L2; B2REB2; B2REB3; Q70W33; Q8NCY0; Q96E80; Q96FM3; Q9UFJ5

Genbank Protein ID

AJ519841; AL355574; AL158822; AL353636; AL158822; AL353636; AL355574; AL353636; AL158822; AL355574; AL355574; AL158822; AL353636; AL353636; AL158822; AL355574; AL353636; AL158822; AL158822; AL353636; AL355574; AL158822; AL353636; BC010646; BC012778; BC130580; AL117634; AL834528

Genbank Nucleotide ID

CAD58627.1; CAI14116.2; CAI14116.2; CAI14116.2; CAI39237.2; CAI39237.2; CAI39237.2; CAI40811.2; CAI40811.2; CAI40811.2; CAQ52438.1; CAQ52438.1; CAQ52438.1; CAQ52575.1; CAQ52575.1; CAQ52575.1; CAQ52576.1; CAQ52576.1; CAQ52650.1; CAQ52650.1; CAQ52650.1; CAQ52651.1; CAQ52651.1; AAH10646.1; AAH12778.2; AAI30581.1; CAB56024.2; CAD39184.1

Protein Name

Calmodulin-regulated spectrin-associated protein 1

Protein Synonyms/Alias

Gene Name

CAMSAP1

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
49	NLQWICAKAYGRDNI	ubiquitination	[1, 2]
897	RAIEAQKKKMEALSA	acetylation	[3]
1341	KARRELIKQEYLRRK	ubiquitination	[1]

Reference

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]

Functional Description

Plays a role in the regulation of cell morphology and cytoskeletal organization.

Sequence Annotation

DOMAIN 183 328 CH.
DOMAIN 1463 1597 CKK.
MOD_RES 217 217 Phosphoserine.
MOD_RES 371 371 Phosphoserine.
MOD_RES 375 375 Phosphoserine.
MOD_RES 512 512 Phosphothreonine.
MOD_RES 575 575 Phosphoserine.
MOD_RES 589 589 Phosphoserine.
MOD_RES 722 722 Phosphoserine.
MOD_RES 1537 1537 Phosphotyrosine.

Keyword

Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1602 AA

Protein Sequence

MVDASGRAAA EGWRKMEAPP DGAADLVPLD RYDAARAKIA ANLQWICAKA YGRDNIPEDL 60
RDPFYVDQYE QEHIKPPVIK LLLSSELYCR VCSLILKGDQ VAALQGHQSV IQALSRKGIY 120
VMESDDTPVT ESDLSRAPIK MSAHMAMVDA LMMAYTVEMI SIEKVVASVK RFSTFSASKE 180
LPYDLEDAMV FWINKVNLKM REITEKEVKL KQQLLESPAH QKVRYRREHL SARQSPYFPL 240
LEDLMRDGSD GAALLAVIHY YCPEQMKLDD ICLKEVTSMA DSLYNIRLLR EFSNEYLNKC 300
FYLTLEDMLY APLVLKPNVM VFIAELFWWF ENVKPDFVQP RDVQELKDAK TVLHQKSSRP 360
PVPISNATKR SFLGSPAAGT LAELQPPVQL PAEGCHRHYL HPEEPEYLGK GTAAFSPSHP 420
LLPLRQKQQK SIQGEDIPDQ RHRSNSLTRV DGQPRGAAIA WPEKKTRPAS QPTPFALHHA 480
ASCEVDPSSG DSISLARSIS KDSLASNIVN LTPQNQPHPT ATKSHGKSLL SNVSIEDEEE 540
ELVAIVRADV VPQQADPEFP RASPRALGLT ANARSPQGQL DTSESKPDSF FLEPLMPAVL 600
KPAKEKQVIT KEDERGEGRP RSIVSRRPSE GPQPLVRRKM TGSRDLNRTF TPIPCSEFPM 660
GIDPTETGPL SVETAGEVCG GPLALGGFDP FPQGPSTDGF FLHVGRADED TEGRLYVSCS 720
KSPNSHDSEP WTLLRQDSDS DVVDIEEAEH DFMGEAHPVV FSRYIGEEES AKLQEDMKVK 780
EHEDKDDASG RSSPCLSTAS QMSSVSMASG SVKMTSFAER KLQRLNSCET KSSTSSSQKT 840
TPDASESCPA PLTTWRQKRE QSPSQHGKDP ASLLASELVQ LHMQLEEKRR AIEAQKKKME 900
ALSARQRLKL GKAAFLHVVK KGKAEAAPPL RPEHFAKEYS QHNGEDCGDA VSKTEDFLVK 960
EEQREELLHE PQDVDKESLA FAQQHKAKDP VALHELERNK VISAALLEDT VGEVVDVNEC 1020
DLSIEKLNET ISTLQQAILK ISQQQEQLLM KSPTVPVPGS KNNSQDHKVK APVHFVEPLS 1080
PTGVAGHRKA PRLGQGRNSR SGRPAELKVP KDRPQGSSRS KTPTPSVETL PHLRPFPASS 1140
HPRTPTDPGL DSALEPSGDP HGKCLFDSYR LHDESNQRTL TLSSSKDANI LSEQMSLKEV 1200
LDASVKEVGS SSSDVSGKES VPVEEPLRSR ASLIEVDLSD LKAPDEDGEL VSLDGSADLV 1260
SEGDQKPGVG FFFKDEQKAE DELAKKRAAF LLKQQRKAEE ARVRKQQLEA EVELKRDEAR 1320
RKAEEDRVRK EEEKARRELI KQEYLRRKQQ QILEEQGLGK PKSKPKKPRP KSVHREESCS 1380
DSGTKCSSTP DNLSRTQSGS SLSLASAATT EPESVHSGGT PSQRVESMEA LPILSRNPSR 1440
STDRDWETAS AASSLASVAE YTGPKLFKEP SSKSNKPIIH NAISHCCLAG KVNEPHKNSI 1500
LEELEKCDAN HYIILFRDAG CQFRALYCYY PDTEEIYKLT GTGPKNITKK MIDKLYKYSS 1560
DRKQFNLIPA KTMSVSVDAL TIHNHLWQPK RPAVPKKAQT RK 1602

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB.

Interpro

IPR022613; CAMSAP_CH.
IPR001715; CH-domain.
IPR014797; CKK_domain.
IPR011033; PRC_barrel-like.

Pfam

PF11971; CAMSAP_CH
PF08683; CAMSAP_CKK

SMART

SM01051; CAMSAP_CKK

PROSITE

PS50021; CH
PS51508; CKK

PRINTS