UniProt Accession

 CX7A2_HUMAN; P14406; B2R5E1; Q3MIH5; Q5TF59; Q6FGI2 

Genbank Protein ID

 X15822; AF134406; CR407646; CR542125; AK312154; AL080250; BC101826; BC101828 

Genbank Nucleotide ID

 CAA33820.1; AAF61396.1; CAG28574.1; CAG46922.1; BAG35088.1; CAI19899.1; AAI01827.1; AAI01829.1 

Protein Name

 Cytochrome c oxidase subunit 7A2, mitochondrial 

Protein Synonyms/Alias

 Cytochrome c oxidase subunit VIIa-liver/heart; Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIaL 

Gene Name

 COX7A2 

Gene Synonyms/Alias

 COX7AL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	NKVPEKQKLFQEDDE	ubiquitination	[1, 2]
46	DEIPLYLKGGVADAL	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 

Sequence Annotation

  

Keyword

 Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 83 AA 

Protein Sequence

Gene Ontology

 GO:0005746; C:mitochondrial respiratory chain; IEA:InterPro.
 GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
 GO:0009055; F:electron carrier activity; IEA:InterPro. 

Interpro

 IPR003177; Cyt_c_oxidase_su7a. 

Pfam

 PF02238; COX7a 

SMART

  

PROSITE

  

PRINTS