CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024888
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Breast cancer anti-estrogen resistance 2 
Protein Synonyms/Alias
 Transcriptional-regulating factor 1 
Gene Name
 BCAR2 
Gene Synonyms/Alias
 TRERF1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
72LGLPVGSKNLGQMDTubiquitination[1, 2]
188LRQLLSQKPMEPPAPubiquitination[1, 2, 3]
408QREDSQLKTYSSDRQubiquitination[1]
832HKATLVWKPWPELENubiquitination[1, 4]
1174LDQLSLIKPIKDVDIacetylation[5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1220 AA 
Protein Sequence
MGDQQLYKTN HVAHGSENLF YQQPPLGVHS GLNHNYGNAV TGGGMDAPQA SPISPHFPQD 60
TRDGLGLPVG SKNLGQMDTS RQGGWGSHAG PGNHVQLRGN LANSNMMWGA PAQAEPTDGY 120
QYTYSQASEI RTQKLTSGVL HKLDSFTQVF ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA 180
LRQLLSQKPM EPPAPAIPSR YQQVPQQPHP GFTGGLSKPA LQVGQHPTQG HLYYDYQQPL 240
AQVPVQGGQP LQAPQMLSQH MQQMQQHQYY PPQQQQQAGQ QRISMQEIQT QPQQIRPSQP 300
QPPPQQQQPQ QLQLQQRQGS MQIPQYYQPQ PMMQHLQEQQ QQQMHLQPPS YHRDPHQYTP 360
EQAHTVQLIP LGSMSQYYYQ EPQQPYSHPL YQQSHLSQHQ QREDSQLKTY SSDRQAQAML 420
SSHGDLGPPD TGMGDPASSD LTRVSSTLPH RPLLSPSGIH LNNMGPQHQQ LSPSAMWPQM 480
HLPDGRAQPG SPESSGQPKG AFGEQFDAKN KLTCSICLKE FKNLPALNGH MRSHGGMRAS 540
PNLKQEEGEK VLPPQPQPPL PPPPPPPPPP QLPPEAESLT PMVMPVSVPV KLLPPKPSSQ 600
GFTNSTVAAP SARDKPASSM SDDEMPVLVR MTLSPPHSPQ GAAPRTPAEI PRKHQPSVPK 660
AEEPLKTVQE KKKFRHRPEP LFIPPPPSYN PNPAASYSGA TLYQSQLRSP RVLGDHLLLD 720
PTHELPPYTP PPMLSPVRQG SGLFSNVLIS GHGPGAHPQL PLTPLTPTPR VLLCRSNSID 780
GSNVTVTPGP GEQTVDVEPR INIGLRFQAE IPELQDISAL AQDTHKATLV WKPWPELENH 840
DLQQRVENLL NLCCSSALPG GGTNSEFALH SLFEAKGDVM VALEMLLLRK PVRLKCHPLA 900
NYHYAGSDKW TSLERKLFNK ALATYSKDFI FVQKMVKSKT VAQCVEYYYT WKKIMRLGRK 960
HRTRLAEIID DCVTSEEEEE LEEEEEEDPE EDRKSTKEEE SEVPKSPEPP PVPVLAPTEG 1020
PPLQALGQPS GSFICEMPNC GAVFSSRQAL NGHARIHGGT NQVTKARGAI PSGKQKPGGT 1080
QSGYCSVKSS PSHSTTSGET DPTTIFPCKE CGKVFFKIKS RNAHMKTHRQ QEEQQRQKAQ 1140
KAAFAAEMAA TIERTTGPVG APGLLPLDQL SLIKPIKDVD ILDDDVVQQL GGVMEEAEVV 1200
DTDLLLDDQD SVLLQGDAEL 1220 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR000949; ELM2_dom.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF01448; ELM2 
SMART
 SM00717; SANT
 SM00355; ZnF_C2H2 
PROSITE
 PS51156; ELM2
 PS51293; SANT
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS