UniProt Accession

 S38A1_HUMAN; Q9H2H9; Q8NC61; Q8NCF8; Q96JX2; Q9H2Q2 

Genbank Protein ID

 AF271070; AF247166; AK027825; AK074758; AK074949; CH471111; BC010620 

Genbank Nucleotide ID

 AAG39354.1; AAG44546.1; BAB55394.1; BAC11186.1; BAC11310.1; EAW57895.1; AAH10620.1 

Protein Name

 Sodium-coupled neutral amino acid transporter 1 

Protein Synonyms/Alias

 Amino acid transporter A1; N-system amino acid transporter 2; Solute carrier family 38 member 1; System A amino acid transporter 1; System N amino acid transporter 1 

Gene Name

 SLC38A1 

Gene Synonyms/Alias

 ATA1; NAT2; SAT1; SNAT1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
60	LTNSHLEKKKCDEYI	ubiquitination	[1]
178	NELPSAIKFLMGKEE	ubiquitination	[1, 2]
384	SSLFELAKKTKFNLC	ubiquitination	[1]
387	FELAKKTKFNLCRHT	ubiquitination	[2, 3]
448	ITDQDGDKGTQRIWA	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. 

Sequence Annotation

 MOD_RES 25 25 Phosphoserine.
 MOD_RES 28 28 Phosphoserine.
 MOD_RES 52 52 Phosphoserine.
 MOD_RES 54 54 Phosphothreonine.
 MOD_RES 56 56 Phosphoserine.
 CARBOHYD 251 251 N-linked (GlcNAc...) (Potential).
 CARBOHYD 257 257 N-linked (GlcNAc...) (Potential).  

Keyword

 Amino-acid transport; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 487 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0015186; F:L-glutamine transmembrane transporter activity; IEA:Compara.
 GO:0015175; F:neutral amino acid transmembrane transporter activity; NAS:UniProtKB.
 GO:0005283; F:sodium:amino acid symporter activity; NAS:UniProtKB.
 GO:0001504; P:neurotransmitter uptake; TAS:Reactome. 

Interpro

 IPR013057; AA_transpt_TM. 

Pfam

 PF01490; Aa_trans 

SMART

  

PROSITE

  

PRINTS