| Tag | Content |
|---|
| CPLM ID | CPLM-008529 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 136 |
Protein Synonyms/Alias | |
Gene Name | ZNF136 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 138 | EYQEYGEKPDTRNQC | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain. |
Sequence Annotation | DOMAIN 4 90 KRAB.
ZN_FING 140 162 C2H2-type 1; degenerate.
ZN_FING 168 190 C2H2-type 2.
ZN_FING 196 218 C2H2-type 3.
ZN_FING 224 246 C2H2-type 4.
ZN_FING 252 274 C2H2-type 5.
ZN_FING 280 302 C2H2-type 6.
ZN_FING 308 330 C2H2-type 7.
ZN_FING 336 358 C2H2-type 8.
ZN_FING 364 386 C2H2-type 9.
ZN_FING 392 414 C2H2-type 10.
ZN_FING 420 442 C2H2-type 11.
ZN_FING 448 470 C2H2-type 12.
ZN_FING 476 498 C2H2-type 13.
ZN_FING 504 526 C2H2-type 14. |
Keyword | Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 540 AA |
Protein Sequence | MDSVAFEDVD VNFTQEEWAL LDPSQKNLYR DVMWETMRNL ASIGKKWKDQ NIKDHYKHRG 60
RNLRSHMLER LYQTKDGSQR GGIFSQFANQ NLSKKIPGVK LCESIVYGEV SMGQSSLNRH 120
IKDHSGHEPK EYQEYGEKPD TRNQCWKPFS SHHSFRTHEI IHTGEKLYDC KECGKTFFSL 180
KRIRRHIITH SGYTPYKCKV CGKAFDYPSR FRTHERSHTG EKPYECQECG KAFTCITSVR 240
RHMIKHTGDG PYKCKVCGKP FHSLSSFQVH ERIHTGEKPF KCKQCGKAFS CSPTLRIHER 300
THTGEKPYEC KQCGKAFSYL PSLRLHERIH TGEKPFVCKQ CGKAFRSAST FQIHERTHTG 360
EKPYECKECG EAFSCIPSMR RHMIKHTGEG PYKCKVCGKP FHSLSPFRIH ERTHTGEKPY 420
VCKHCGKAFV SSTSIRIHER THTGEKPYEC KQCGKAFSYL NSFRTHEMIH TGEKPFECKR 480
CGKAFRSSSS FRLHERTHTG QKPYHCKECG KAYSCRASFQ RHMLTHAEDG PPYKCMWESL 540 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003714; F:transcription corepressor activity; TAS:ProtInc. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |