UniProt Accession

 SUH_MOUSE; P31266; Q80UN8; Q8C4Z3 

Genbank Protein ID

 S63463; X17459; X58337; M81867; M81865; M81866; M81868; M81870; M81869; M81873; M81872; M81875; M81874; M81876; M81877; BC051387; AK080359 

Genbank Nucleotide ID

 AAB20195.1; CAA35501.1; AAA39018.1; AAA39018.1; AAA39018.1; AAA39019.1; AAA39020.1; AAA39020.1; AAA39021.1; AAA39021.1; AAA39022.1; AAA39022.1; AAA39023.1; AAH51387.1; BAC37889.1 

Protein Name

 Recombining binding protein suppressor of hairless 

Protein Synonyms/Alias

 J kappa-recombination signal-binding protein; RBP-J kappa 

Gene Name

 Rbpj 

Gene Synonyms/Alias

 Igkjrb1; Igkrsbp; Rbpsuh 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
341	FQATPCPKEQNKEMI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. 

Sequence Annotation

 DOMAIN 381 471 IPT/TIG.
 DNA_BIND 84 91 By similarity.
 DNA_BIND 218 227
 DNA_BIND 291 323  

Keyword

 3D-structure; Activator; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Notch signaling pathway; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 526 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:InterPro.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISO:MGI.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:MGI.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0036302; P:atrioventricular canal development; IMP:BHF-UCL.
 GO:0009912; P:auditory receptor cell fate commitment; IMP:MGI.
 GO:0030183; P:B cell differentiation; IMP:MGI.
 GO:0097101; P:blood vessel endothelial cell fate specification; IGI:BHF-UCL.
 GO:0072554; P:blood vessel lumenization; IMP:BHF-UCL.
 GO:0001974; P:blood vessel remodeling; IMP:BHF-UCL.
 GO:0003214; P:cardiac left ventricle morphogenesis; IMP:BHF-UCL.
 GO:0042742; P:defense response to bacterium; IMP:MGI.
 GO:0035912; P:dorsal aorta morphogenesis; IMP:BHF-UCL.
 GO:0003160; P:endocardium morphogenesis; IMP:BHF-UCL.
 GO:0009957; P:epidermal cell fate specification; IMP:MGI.
 GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IMP:BHF-UCL.
 GO:0048820; P:hair follicle maturation; IMP:MGI.
 GO:0001947; P:heart looping; TAS:BHF-UCL.
 GO:0006959; P:humoral immune response; IMP:MGI.
 GO:0002437; P:inflammatory response to antigenic stimulus; IMP:MGI.
 GO:0072602; P:interleukin-4 secretion; IMP:MGI.
 GO:0030216; P:keratinocyte differentiation; IMP:MGI.
 GO:0060716; P:labyrinthine layer blood vessel development; IMP:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0030279; P:negative regulation of ossification; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0060853; P:Notch signaling pathway involved in arterial endothelial cell fate commitment; IC:BHF-UCL.
 GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
 GO:0021983; P:pituitary gland development; IMP:MGI.
 GO:0030513; P:positive regulation of BMP signaling pathway; IMP:BHF-UCL.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IMP:BHF-UCL.
 GO:2000138; P:positive regulation of cell proliferation involved in heart morphogenesis; IMP:BHF-UCL.
 GO:1901189; P:positive regulation of ephrin receptor signaling pathway; IMP:BHF-UCL.
 GO:1901186; P:positive regulation of ERBB signaling pathway; IMP:BHF-UCL.
 GO:0035481; P:positive regulation of Notch signaling pathway involved in heart induction; TAS:BHF-UCL.
 GO:0007221; P:positive regulation of transcription of Notch receptor target; ISS:UniProtKB.
 GO:0061344; P:regulation of cell adhesion involved in heart morphogenesis; IC:BHF-UCL.
 GO:0048505; P:regulation of timing of cell differentiation; IMP:MGI.
 GO:0003256; P:regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; IMP:BHF-UCL.
 GO:0048733; P:sebaceous gland development; IMP:MGI.
 GO:0035019; P:somatic stem cell maintenance; IMP:MGI.
 GO:0001756; P:somitogenesis; TAS:BHF-UCL.
 GO:0003222; P:ventricular trabecula myocardium morphogenesis; IMP:BHF-UCL. 

Interpro

 IPR015350; Beta-trefoil_DNA-bd_dom.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR015351; LAG1_DNA-bd.
 IPR008967; p53-like_TF_DNA-bd. 

Pfam

 PF09270; BTD
 PF09271; LAG1-DNAbind
 PF01833; TIG 

SMART

  

PROSITE

  

PRINTS