CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012884
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acyl-coenzyme A thioesterase 10, mitochondrial 
Protein Synonyms/Alias
 Acyl-CoA thioesterase 10; Mitochondrial 48 kDa acyl-CoA thioester hydrolase 2; Mt-ACT48.2 
Gene Name
 Acot10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
102TDPELRDKYVTVQNTacetylation[1, 2, 3, 4, 5, 6]
102TDPELRDKYVTVQNTsuccinylation[5]
250FSTSSLLKVAPSSEEacetylation[4]
292AVWMEDTKLKSLDICacetylation[5]
292AVWMEDTKLKSLDICsuccinylation[5]
294WMEDTKLKSLDICHPacetylation[5]
294WMEDTKLKSLDICHPsuccinylation[5]
423LDGQRHFKSMSTPVTacetylation[3]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. 
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Mitochondrion; Reference proteome; Serine esterase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 439 AA 
Protein Sequence
MKRAAMRLWT LNKGLLTHGR GLSQGSQYKI SEPLHIHQVQ VKLREIVGIS TVWRDHVQAM 60
EERKLLHSFL PKSQKVLPPR KIRDSYIEVL LPLGTDPELR DKYVTVQNTV RFGRILEDLD 120
SLGVLVCYMH NHNHSTNMSL LSIVTVLVDK IDMCKHSLSP EQDIKFTGHV SWVGNTTMEV 180
KMKMFQLHDD ETYWPVLDAT FVMVAQDSEN KRPAFVNPLI PENKEEEELF TQGELNKSRR 240
IAFSTSSLLK VAPSSEERNI IHELFLSTLD PKTISFQSRI LPPKAVWMED TKLKSLDICH 300
PQERNVFNRI FGGFLMRKAY ELAWATACSF GGSRPYVVTV DDIMFQKPVE VGSLLFLSSQ 360
VCFTQGNYIQ VRVHSEVFSL DSREHMTTNV FHFTFMSEKE VPLIFPKTYG ESMLYLDGQR 420
HFKSMSTPVT LKKDYPVEP 439 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0047617; F:acyl-CoA hydrolase activity; IDA:MGI.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0006637; P:acyl-CoA metabolic process; TAS:MGI. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS