CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015042
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine--tRNA ligase 
Protein Synonyms/Alias
 Tyrosyl-tRNA synthetase; TyrRS 
Gene Name
 tyrS 
Gene Synonyms/Alias
 RPA2460 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
103YEQIDANKESIKGTFacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131
Functional Description
 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity). 
Sequence Annotation
 DOMAIN 350 418 S4 RNA-binding.
 MOTIF 44 53 "HIGH" region.
 MOTIF 236 240 "KMSKS" region.
 BINDING 39 39 Tyrosine (By similarity).
 BINDING 176 176 Tyrosine (By similarity).
 BINDING 180 180 Tyrosine (By similarity).
 BINDING 239 239 ATP (By similarity).  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MTAFKSDFMN VLQSRGFIHQ ISDPDSLDAL AAKGEVVAYV GYDCTAASLH VGHLLSIMML 60
HWLQATGNKP IALMGGGTTR VGDPSGRDET RKILTYEQID ANKESIKGTF SKFIKFGDGH 120
SDALMADNAE WLTKLNYIEM LREIGRHFSI NRMLTMDSVK LRLDREQELS FIEFNYMILQ 180
SYDFVELARR YKCNLQMGGS DQWGNIVTGV DLGRRMGTHQ LHALTCPLLT TASGAKMGKT 240
AAGAVWLNGD MLAPYDYWQY WRNTEDADVG RFLKLFTLLP MDEIERLSKL QGAEINDAKK 300
ILATEATALM HGREAADKAE TTARTTFEQG GTAQDLPSVE ISRGELDAGI GVLVAFAEKT 360
GLVASNGEAR RQIKAGGLKV NDAPVTDEKM TLTATDLSSD GVIKLSMGKK KHVLLRLA 418 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0004831; F:tyrosine-tRNA ligase activity; IEA:HAMAP.
 GO:0006437; P:tyrosyl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR002305; aa-tRNA-synth_Ic.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR002942; S4_RNA-bd.
 IPR002307; Tyr-tRNA-ligase.
 IPR024088; Tyr-tRNA-ligase_bac-type.
 IPR024107; Tyr-tRNA-ligase_bac_1. 
Pfam
 PF00579; tRNA-synt_1b 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I
 PS50889; S4 
PRINTS
 PR01040; TRNASYNTHTYR.