CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041090
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Hsc70-interacting protein 
Protein Synonyms/Alias
  
Gene Name
 St13 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
150KRASVFVKLQKPNAAacetylation[1]
150KRASVFVKLQKPNAAubiquitination[2]
176PDSAQPYKWRGKAHRacetylation[3, 4]
176PDSAQPYKWRGKAHRubiquitination[2]
346SKYQSNPKVMNLISKacetylation[3, 5]
346SKYQSNPKVMNLISKubiquitination[2]
353KVMNLISKLSAKFGGacetylation[3, 5]
353KVMNLISKLSAKFGGubiquitination[2]
357LISKLSAKFGGQS**ubiquitination[2]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MDPRKVSELR AFVKMCRQDP SVLHTEEMRF LREWVESMGG KVPPATHKAK SEENTKENIK 60
TEELSSEESD LEIDNEGVIE PDTDAPQEMG DENAEITEEM MDEANEKKGA AIEALNDGEL 120
QKAIDLFTDA IKLNPRLAIL YAKRASVFVK LQKPNAAIRD CDRAIEINPD SAQPYKWRGK 180
AHRLLGHWEE AAHDLALACK LDYDEDASAM LREVQPRAQK IAEHRRKYER KREEREIKER 240
IERVKKAREE HERAQREEEA RRQSGSQYGS FPGGFPGGMP GNFPGGMPGM GGAMPGMAGM 300
AGMPGLNEIL SDPEVLAAMQ DPEVMVAFQD VAQNPSNMSK YQSNPKVMNL ISKLSAKFGG 360
QS 362 
Gene Ontology
  
Interpro
 IPR006636; STI1_HS-bd.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF07719; TPR_2 
SMART
 SM00727; STI1
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS